Cognitive impairment is now widely considered to be a central feature of schizophrenia. The vast majority of patients with the illness demonstrate clear deficits relative to healthy controls, most often reported in, domains of controlled attention, working memory, learning and episodic memory, and reasoning/executive, functions. It is quite clear that practice- and instruction-based remediation interventions can lead to narrow, changes in cognitive performance in patients. However, much of the existing body of work relevant to, cognitive remediation in schizophrenia has been experimental, rather than clinical, with narrow aims., We seek funding (under PA-99-134) to develop a standardized computer-assisted cognitive remediation (CACR) program for schizophrenia patients. CACR addresses 'cognitive control' and certain underlying cognitive processes. The intervention features: 1) strategy training; 2) guided cognitive exercise; 3) use of selected computer learning activities; and 4) a supportive, one-on-one training model. Preliminary work has helped us identify these components and meld them into a workable, promising program. The program needs to be further standardized and piloted before it can be examined in a large clinical trial.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21MH067764-01A1
Application #
6730301
Study Section
Special Emphasis Panel (ZRG1-BBBP-5 (01))
Program Officer
Heinssen, Robert K
Project Start
2003-12-01
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
1
Fiscal Year
2004
Total Cost
$185,625
Indirect Cost
Name
University of Maryland Baltimore
Department
Psychiatry
Type
Schools of Medicine
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Dickinson, Dwight; Tenhula, Wendy; Morris, Sarah et al. (2010) A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia. Am J Psychiatry 167:170-80
Dickinson, Dwight; Ragland, J Daniel; Gold, James M et al. (2008) General and specific cognitive deficits in schizophrenia: Goliath defeats David? Biol Psychiatry 64:823-7
Dickinson, Dwight; Ramsey, Mary E; Gold, James M (2007) Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Arch Gen Psychiatry 64:532-42
Dickinson, Dwight; Bellack, Alan S; Gold, James M (2007) Social/communication skills, cognition, and vocational functioning in schizophrenia. Schizophr Bull 33:1213-20
Dickinson, Dwight; Ragland, J Daniel; Calkins, Monica E et al. (2006) A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis. Schizophr Res 85:20-9