A fundamental question in managing sciatica pain remains unanswered: Is chronic sciatica pain mediated by persistent inflammation? Sciatica refers to back pain with a radicular component. Sciatica pain accounts for up to 40% of all back pain, which is a leading cause of lost workdays in the US, costs employers an estimated $7.4 billion/year, and is the main reason for disability in Americans under 45 years old. Among the main causes of sciatica pain are intervertebral disk displacement and stenosis of the intervertebral foramen producing inflammation of neural structures and severe pain. Interlaminar and transforaminal injection of epidural steroids are extensively used to treat sciatica. The rationale is that reduction in regional inflammation promoted by steroids will lead to improvement of symptoms. However, there is very limited evidence on the association between structural abnormalities in the vertebral column, corresponding inflammatory changes around nerve roots, and sensory or motor symptoms associated with back and sciatica pain. There is also significant doubt on the effectiveness of steroid injections for treatment. Magnetic resonance imaging (MRI) is the main imaging technique to assess structural changes associated with pain of spinal origin. Recently, advances in Positron Emission Tomography (PET) introduced the tracer [11C]PBR28 to specifically investigate neuroinflammation. Availability of PET/MRI cameras offers a unique opportunity to study the association between neuroinflammation and structural changes in this major medical problem. We propose to use PET/MRI with [11C]PBR28 to study the association between inflammation, structural changes, symptoms and treatment outcome in patients with sciatica. The ability to image neuraxial inflammation developed in this study has the potential to revolutionize the diagnosis and treatment of low back pain. We plan to perform a pilot study of [11C]PBR28 PET/MRI of the lumbosacral spine in patients with sciatica pain to establish this methodology and explore the role of this technology in guiding clinical treatment of sciatica pain.

Public Health Relevance

Chronic sciatica pain is a common condition with significant socioeconomic impact. The treatment outcome is far from satisfactory. We propose to use PET/MRI with a novel inflammatory tracer to study the association between inflammation, structural changes, and symptoms in patients with sciatica pain. The result of this study will provide key information to understand the mechanism of chronic sciatica pain and provide rationale of optimal treatment stratification.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21NS082548-01A1
Application #
8637415
Study Section
Special Emphasis Panel (ZRG1-DTCS-A (81))
Program Officer
Porter, Linda L
Project Start
2013-09-15
Project End
2015-08-31
Budget Start
2013-09-15
Budget End
2014-08-31
Support Year
1
Fiscal Year
2013
Total Cost
$217,500
Indirect Cost
$92,500
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199