Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Unknown (R23)
Project #
5R23DK035469-02
Application #
3447358
Study Section
Nutrition Study Section (NTN)
Project Start
1985-08-01
Project End
1988-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Britton, R S; O'Neill, R; Bacon, B R (1991) Chronic dietary iron overload in rats results in impaired calcium sequestration by hepatic mitochondria and microsomes [corrected] Gastroenterology 101:806-11
Britton, R S; O'Neill, R; Bacon, B R (1990) Hepatic mitochondrial malondialdehyde metabolism in rats with chronic iron overload. Hepatology 11:93-7
Britton, R S; Ferrali, M; Magiera, C J et al. (1990) Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload. Hepatology 11:1038-43
Sharma, B K; Bacon, B R; Britton, R S et al. (1990) Prevention of hepatocyte injury and lipid peroxidation by iron chelators and alpha-tocopherol in isolated iron-loaded rat hepatocytes. Hepatology 12:31-9
Bacon, B R; Britton, R S (1990) The pathology of hepatic iron overload: a free radical--mediated process? Hepatology 11:127-37
Nichols, G M; Bacon, B R (1989) Hereditary hemochromatosis: pathogenesis and clinical features of a common disease. Am J Gastroenterol 84:851-62
Weissleder, R; Stark, D D; Engelstad, B L et al. (1989) Superparamagnetic iron oxide: pharmacokinetics and toxicity. AJR Am J Roentgenol 152:167-73
Bacon, B R; Britton, R S; O'Neill, R (1989) Effects of vitamin E deficiency on hepatic mitochondrial lipid peroxidation and oxidative metabolism in rats with chronic dietary iron overload. Hepatology 9:398-404
Bacon, B R; Britton, R S (1989) Hepatic injury in chronic iron overload. Role of lipid peroxidation. Chem Biol Interact 70:183-226
Feldman, E S; Bacon, B R (1989) Hepatic mitochondrial oxidative metabolism and lipid peroxidation in experimental hexachlorobenzene-induced porphyria with dietary carbonyl iron overload. Hepatology 9:686-92

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