The Harvard Brain Tissue Resource Center (HBTRC) is a national resource for the acquisition, processing, storage and distribution of high quality postmortem (PM) brain tissue to the neuroscience community. The HBTRC collects brains from individuals with a variety of movement disorders (Huntington's chorea and Parkinson's disease), dementias (Alzheimer's disease, frontotemporal dementias), major psychoses (schizophrenia and bipolar disorder) and autism. A key aspect of its functioning involves the acquisition of 70 normal controls representing a broad range of ages. During the current funding period, the HBTRC has continued its core value of maintaining the quality and efficiency of its operation. Each year, the HBTRC collects approximately 275-300 brains and distributes thousands of tissue samples to investigators in the U.S. and abroad. As a result of this effort, the HBTRC provides neuroscientists with well-characterized cohorts consisting of CONs and diseased brains matched for age, PMI, gender and hemisphere. Since almost all of our cases are obtained through community-based referrals, the potential confounding effects of institutionalization, inanition and substance abuse are minimized. To facilitate the donation and processing of brains, the HBTRC has a website with all the necessary forms including a) the Informed Consent for the donor families, b) instructions for handling brains by pathologists or dieners involved in removal, and c) application forms for investigators seeking tissue for their research. The HBTRC also has a User-Interactive Database, so that investigators who receive tissue from the "brain bank" can obtain critical information, such as demographics and neuropathology reports, as well as images of gross dissections and histological slides;To enhance the utility of our tissue, the HBTRC performs gene expression profiling on key regions of interest for each disorder and "deposits" this data in the National Brain Databank (NBD), a public domain repository from which investigators receiving tissue from the HBTRC can download this raw data. In turn, these investigators are encouraged to "deposit" their findings in the NBD so that colleagues studying the same disorder can use them for their respective studies. Over the next funding period, the HBTRC will continue its role as a vital national resource for the distribution of well-characterized, high quality tissue to the neuroscience community.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Resource-Related Research Projects (R24)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-S (04))
Program Officer
Meinecke, Douglas L
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mclean Hospital
United States
Zip Code
Shook, Brett A; Lennington, Jessica B; Acabchuk, Rebecca L et al. (2014) Ventriculomegaly associated with ependymal gliosis and declines in barrier integrity in the aging human and mouse brain. Aging Cell 13:340-50
Shahani, Neelam; Pryor, William; Swarnkar, Supriya et al. (2014) Rheb GTPase regulates *-secretase levels and amyloid * generation. J Biol Chem 289:5799-808
Meulendyke, Kelly A; Ubaida-Mohien, Ceereena; Drewes, Julia L et al. (2014) Elevated brain monoamine oxidase activity in SIV- and HIV-associated neurological disease. J Infect Dis 210:904-12
Pretto, Dalyir I; Kumar, Madhur; Cao, Zhengyu et al. (2014) Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome. Neurobiol Aging 35:1189-97
Fatemi, S Hossein; Reutiman, Teri J; Folsom, Timothy D et al. (2014) Downregulation of GABAA receptor protein subunits ?6, ?2, ?, ?, ?2, ?, and ?2 in superior frontal cortex of subjects with autism. J Autism Dev Disord 44:1833-45
Zhubi, A; Chen, Y; Dong, E et al. (2014) Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum. Transl Psychiatry 4:e349
Butler, Tracy; Zaborszky, Laszlo; Pirraglia, Elizabeth et al. (2014) Comparison of human septal nuclei MRI measurements using automated segmentation and a new manual protocol based on histology. Neuroimage 97:245-51
Ren, Xinguo; Rizavi, Hooriyah S; Khan, Mansoor A et al. (2014) Alteration of cyclic-AMP response element binding protein in the postmortem brain of subjects with bipolar disorder and schizophrenia. J Affect Disord 152-154:326-33
Narayanan, Manikandan; Huynh, Jimmy L; Wang, Kai et al. (2014) Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases. Mol Syst Biol 10:743
Kim, B M; You, M-H; Chen, C-H et al. (2014) Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function. Cell Death Dis 5:e1237

Showing the most recent 10 out of 107 publications