? ? This application represents the renewal of National Neurological AIDS Bank (NNAB), a member of the National Neuro-AIDS Tissue Consortium (NNTC). NNAB is a longitudinal study of well-characterized subjects with advanced AIDS and HIV-seronegative (HIV-) subjects, who have agreed to have serial neurological and neuropsychological examinations during their life, and to donate blood, urine and cerebrospinal fluid (CSF) during life and their organs and tissues after their death. NNAB collects these tissues and organs and distributes them to qualified investigators for research into the pathogenesis of Neuro-AIDS. NNAB characterizes its cohort using standardized NNTC protocols in Neuromedicine, Neuropsychology, Psychiatry/Substance Abuse, and Neuropathology, to achieve consensus diagnoses that are monitored by the NNTC Quality Assurance Committees. In addition, NNAB independently collects information that is essential to study the association between co-morbid medical conditions, such as Hepatitis C virus (HCV) infection, hypertension, diabetes, lipid disorders, as well as the adverse effects of retroviral therapy and HIV neurological disease. The NNAB cohort is unique because of its diversity, and reflects the gender, ethnic, and racial distribution of AIDS in Los Angeles. NNAB is 85% male and 15% female; over 60% of our cohort is a member of racial and ethnic minorities, 20% are monolingual in Spanish, and 8% have less than 6 years of education. In this renewal, we plan to expand our cohort, utilizing our collaborations among UCLA Medical Center, Olive View-UCLA Medical Center, Charles R. Drew University, and USC University Hospital. NNAB has stimulated the development of independently funded projects studying CSF viral load, HCV and the nervous system, and magnetic resonance spectroscopy (MRS) as a tool for following HIV neurological disease. These projects and the information they generate further enrich the value of our tissue collection. NNAB provides an increasingly important resource that mirrors the changing face of the AIDS epidemic and is capable of adapting as the needs of investigators dictate. NNAB provides an invaluable resource to the NNTC, the scientific community, and people living with AIDS. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Resource-Related Research Projects (R24)
Project #
2R24NS038841-06A1
Application #
6747075
Study Section
Special Emphasis Panel (ZNS1-SRB-A (01))
Program Officer
Nunn, Michael
Project Start
1998-09-30
Project End
2008-05-31
Budget Start
2003-09-30
Budget End
2004-05-31
Support Year
6
Fiscal Year
2003
Total Cost
$1,037,807
Indirect Cost
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Levine, Andrew J; Soontornniyomkij, Virawudh; Achim, Cristian L et al. (2016) Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. J Neurovirol 22:431-41
Var, Susanna R; Day, Tyler R C; Vitomirov, Andrej et al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS 30:839-48
Levine, Andrew J; Quach, Austin; Moore, David J et al. (2016) Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders. J Neurovirol 22:366-75
Fogel, Gary B; Lamers, Susanna L; Levine, Andrew J et al. (2015) Factors related to HIV-associated neurocognitive impairment differ with age. J Neurovirol 21:56-65
Horvath, Steve; Levine, Andrew J (2015) HIV-1 Infection Accelerates Age According to the Epigenetic Clock. J Infect Dis 212:1563-73
Dever, Seth M; Rodriguez, Myosotys; Lapierre, Jessica et al. (2015) Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure. Front Microbiol 6:653
Zenón, Frances; Cantres-Rosario, Yisel; Adiga, Radhika et al. (2015) HIV-infected microglia mediate cathepsin B-induced neurotoxicity. J Neurovirol 21:544-58
Silva, Katie; Hope-Lucas, Calixto; White, Tyesha et al. (2015) Cortical neurons are a prominent source of the proinflammatory cytokine osteopontin in HIV-associated neurocognitive disorders. J Neurovirol 21:174-85
Cassol, Edana; Misra, Vikas; Morgello, Susan et al. (2015) Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIV-Negative Subjects With Depression. J Acquir Immune Defic Syndr 69:18-28
Cantres-Rosario, Yisel M; Hernandez, Natalia; Negron, Karla et al. (2015) Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS 29:2081-92

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