This is a renewal application for the Memorial Sloan-Kettering Cancer Center (MSKCC) R25T training grant program, "Molecular Imaging: Training for Oncology" (MITO), which began in 2002. In the last five years, molecular imaging has been established as an outstanding tool for fostering rapid progress in laboratory discovery as well as uniquely individualized patient care. The goal of our program is to train a new generation of imaging researchers, who are sufficiently facile in both modern cancer biology and imaging techniques to lead the rapid development of molecular imaging as a tool for laboratory discovery and individualized clinical care in oncology. The program is managed by an internal advisory committee composed of clinical and basic cancer researchers with experience in graduate medical education in oncology. A distinguished external advisory board composed of leading molecular imaging researchers provides continual feedback and advice. MSKCC offers a unique environment as one of the leading clinical cancer centers in the world that is closely integrated with a research institution (Sloan-Kettering Institute [SKI]). It has an extensive molecular imaging infrastructure, as well as multiple oncology directed PO1s, SPOREs and RO1s with integral imaging components that stress the multimodality biologic imaging of cancer. These research programs provide fertile ground for training and selecting projects for trainees. Mentors are drawn from a distinguished faculty of NCI-supported cancer researchers. Our training program makes use of relationships we have established between the molecular imaging group and basic laboratory programs in cancer biology, tumor immunology, molecular pathology, and molecular pharmacology. It also makes use of translational programs that have been initiated at MSKCC over the last five years, in image-guided intervention, clinical PET research, cyclotron radiochemistry and advanced image analysis including biomarker assessment. A specialized curriculum includes an individualized research program of basic, translational or clinical interdisciplinary research and the relevant molecular biology, research methodology, and advanced imaging methods. Tri-institutional graduate programs from Cornell Medical College, SKI and Rockefeller University provide didactic training. Our diversity enhancement plan offers equal opportunities for minorities and women and includes a MITO Minority Recruitment Committee, participation of the MSKCC Diversity officer, and leadership from the CCNY/MSKCC Partnership. Both basic science and clinical trainees will be recruited. A plan is in place to facilitate placement of our trainees as junior faculty in molecular imaging programs at academic institutions across the country.

Public Health Relevance

Molecular imaging in oncology permits noninvasive detection of the molecules and molecular events that are fundamental to cancer oncogenesis and maintenance of the neoplastic state. Molecular imaging thus has the potential to allow for more rapid progress in fundamental laboratory discovery and to foster uniquely individualized patient care in the clinic. This is an application for a grant to train a new generation of basic and clinical researchers to perform basic, translational and clinical cancer research within the rapidly expanding field of molecular imaging.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA096945-09
Application #
8325932
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2002-08-16
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
9
Fiscal Year
2012
Total Cost
$486,108
Indirect Cost
$39,997
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Cheal, Sarah M; Xu, Hong; Guo, Hong-Fen et al. (2016) Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity ⁸⁶Y- or ¹⁷⁷Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates. Eur J Nucl Med Mol Imaging 43:925-37
Houghton, Jacob L; Zeglis, Brian M; Abdel-Atti, Dalya et al. (2016) Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses. J Nucl Med 57:453-9
Meyer, Jan-Philip; Houghton, Jacob L; Kozlowski, Paul et al. (2016) (18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry. Bioconjug Chem 27:298-301
Huang, Ruimin; Harmsen, Stefan; Samii, Jason M et al. (2016) High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe. Theranostics 6:1075-84
Thorek, Daniel L J; Kramer, Robin M; Chen, Qing et al. (2015) Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models. Int J Radiat Oncol Biol Phys 93:444-53
Harmsen, Stefan; Huang, Ruimin; Wall, Matthew A et al. (2015) Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging. Sci Transl Med 7:271ra7
Lohrmann, Christian; Zhang, Hanwen; Thorek, Daniel L J et al. (2015) Cerenkov Luminescence Imaging for Radiation Dose Calculation of a ⁹⁰Y-Labeled Gastrin-Releasing Peptide Receptor Antagonist. J Nucl Med 56:805-11
Houghton, Jacob L; Zeglis, Brian M; Abdel-Atti, Dalya et al. (2015) Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer. Proc Natl Acad Sci U S A 112:15850-5
Cheal, Sarah M; Xu, Hong; Guo, Hong-fen et al. (2014) Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex. Mol Cancer Ther 13:1803-12
Zhang, Hanwen; Huang, Ruimin; Pillarsetty, NagaVaraKishore et al. (2014) Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter. Eur J Nucl Med Mol Imaging 41:322-32

Showing the most recent 10 out of 63 publications