This proposal is for a competitive renewal of a R25T Cancer Education and Career Development Program for post-doctoral training in Genetic and Molecular Epidemiology of Cancer (GMEC). The current era of cancer research is providing extraordinary tools for understanding the genetic and environmental causes of carcinogenesis. Using these tools to their fullest extent requires input from teams of scientists with a mixture of backgrounds, including molecular biology, oncology, medicine, genetics, epidemiology, and biostatistics. Individuals with trans-disciplinary education across these fields are crucial to the success of such teams. In particular, they can serve as the conduit for the integrated work necessary to accomplish some of the most promising research. However, the focused nature of most training opportunities provides limited opportunities for investigators to obtain the knowledge that bridges these disciplines. To address this issue, we propose renewing for a third time the current GMEC training program. Note that for the previous renewal, Study Section was extremely supportive of this Program, giving it a score of 18 on the first (and only) review. The overall specific aim of this program is to offer a set of instructional and research opportunities o exceptional postdoctoral candidates in order to promote their careers as independent researchers in the interdisciplinary "field" of genetic and molecular epidemiology of cancer. Mentors and research training opportunities will continue to come from major academic and research institutions in the San Francisco Bay Area, including the University of California San Francisco and Berkeley, Kaiser Permanente, Stanford University, and the Cancer Prevention Institute of California. This program is uniquely suited to the R25T grant mechanism because it trains scientists at the intersection of multiple distinct fields. More specifically, the GMEC program blends together in a highly interactive fashion a group of mentors and trainees from cancer research, molecular biology, genetics, epidemiology, and biostatistics. The program is defined by three main components: 1) a specialized core curriculum that covers the key disciplines and their intersections;2) additional educational experiences to complement their research and educational background and interest;and 3) focused research projects with multiple mentors. Each trainee will also be required to extend their research experience by writing a mock NIH proposal. Individuals trained in this program will have the skills vital to deciphering the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.

Public Health Relevance

Individuals trained in this program will have the skills vital to deciphering the causes of cancer, ultimately providing valuable knowledge regarding the prevention and treatment of this complex disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
2R25CA112355-10
Application #
8665615
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2004-12-01
Project End
2019-08-31
Budget Start
2014-09-15
Budget End
2015-08-31
Support Year
10
Fiscal Year
2014
Total Cost
$539,974
Indirect Cost
$39,998
Name
University of California San Francisco
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Walsh, Kyle M; Codd, Veryan; Smirnov, Ivan V et al. (2014) Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet 46:731-5
Magbanua, Mark Jesus M; Richman, Erin L; Sosa, Eduardo V et al. (2014) Physical activity and prostate gene expression in men with low-risk prostate cancer. Cancer Causes Control 25:515-23
de Smith, Adam J; Walsh, Kyle M; Ladner, Martha B et al. (2014) The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood 123:2497-503
Walsh, Kyle M; de Smith, Adam J; Welch, Tara C et al. (2014) Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia. Am J Hematol 89:721-5
Van Blarigan, Erin L; Ma, Jing; Kenfield, Stacey A et al. (2014) Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival. Cancer Epidemiol Biomarkers Prev 23:1037-46
Levin, Albert M; Lindquist, Karla J; Avila, Andrew et al. (2014) Performance of the Genomic Evaluators of Metastatic Prostate Cancer (GEMCaP) tumor biomarker for identifying recurrent disease in African American patients. Cancer Epidemiol Biomarkers Prev 23:1677-82
Walsh, Kyle M; Gorlov, Ivan P; Hansen, Helen M et al. (2013) Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev 22:251-60
Witte, John S; Mefford, Joel; Plummer, Sarah J et al. (2013) HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease. Cancer Epidemiol Biomarkers Prev 22:675-80
Dahlin, Amber; Geier, Ethan; Stocker, Sophie L et al. (2013) Gene expression profiling of transporters in the solute carrier and ATP-binding cassette superfamilies in human eye substructures. Mol Pharm 10:650-63
Stocker, S L; Morrissey, K M; Yee, S W et al. (2013) The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther 93:186-94

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