A NIDA conducted national survey reported that 5.5% of 4 million women who gave birth in the United States in 1992 used illegal drugs while they were pregnant. In addition to the psychosocial ramifications, illicit drug use also has adverse effects on the development of the nervous system in the fetus and newborn and increases the possibilities of risk taking behavior in adolescence. Little is known about the biology of addiction to illicit drugs in the developing fetus and newborn and few investigators specialize in this important field. In response to the program announcement (PAR-04-054), Research Education Grants in Drug Abuse and Addiction, the overall goal of this proposal is to bring together the scientific and educational expertise in drug abuse research at Johns Hopkins and Morgan State University to create a novel educational/research training program with the mission of training researchers in the basic biology and psychosocial aspects of illicit drug use in the young woman entering reproductive age, the pregnant woman, and her fetus and newborn. Under the co-directorship of Estelle Gauda, M.D., a physician-scientist at Johns Hopkins, and Gabrielle McLemore, Ph.D., a educator-scientist at Morgan State University, we have created a partnership between investigators from the Center for Addiction and Pregnancy at Johns Hopkins Bayview Medical Center, the Kennedy Krieger Family Center, the Department of Pediatrics and Adolescent Medicine at Johns Hopkins University, and Morgan State University to accomplish this goal through 2 educational programs. The Summer Immersion in Drug Abuse Research Program (SIDARP) is a 10 week educational-research/training experience which will target doctoral students, medical students, and physicians at an early stage of their professional careers. The Drug Abuse Research Training (DART) Program is a long-term (2-3 years) research experience designed to target pre and postdoctoral students and clinician-scientists to be the next generation of leaders in the field of drug addiction and abuse research and education. The training program will use a competency based learning strategy to maximize learning. Emphasis will be given to having educational and research opportunities that will include basic mechanisms mediating drug dependence and tolerance in the fetus and newborn, effects of opiate exposure on human fetal behavior and newborn brain development, alternative treatment and detoxification strategies for opiate addiction during pregnancy and in the newborn, and drug abuse intervention and prevention strategies in women of reproductive age.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Education Projects (R25)
Project #
5R25DA021630-04
Application #
7848238
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Grossman, Debra
Project Start
2007-07-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
4
Fiscal Year
2010
Total Cost
$335,935
Indirect Cost
Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Bierman, Alexis M; Tankersley, Clarke G; Wilson, Christopher G et al. (2014) Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups. J Appl Physiol (1985) 116:47-53
Miller-Thomas, Tonya; Leoutsakos, Jeannie-Marie S; Terplan, Mishka et al. (2014) Comparison of cigarette smoking knowledge, attitudes, and practices among staff in perinatal and other substance abuse treatment settings. J Addict Med 8:377-83
Kesavan, Kalpashri; Ezell, Tarrah; Bierman, Alexis et al. (2014) Breathing and temperature control disrupted by morphine and stabilized by clonidine in neonatal rats. Respir Physiol Neurobiol 201:93-100
McLemore, Gabrielle L; Lewis, Tamorah; Jones, Catherine H et al. (2013) Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome. Semin Fetal Neonatal Med 18:35-41
Blouin, Ashley M; Lee, Jongah J; Tao, Bo et al. (2013) Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia. Behav Brain Res 257:178-81
Chavez-Valdez, R; Kovell, L; Ahlawat, R et al. (2013) Opioids and clonidine modulate cytokine production and opioid receptor expression in neonatal immune cells. J Perinatol 33:374-82
Hart, Shayla L; Hodgkinson, Stacy C; Belcher, Harolyn M E et al. (2013) Somatic symptoms, peer and school stress, and family and community violence exposure among urban elementary school children. J Behav Med 36:454-65
Blouin, Ashley M; Stern, Anna L; Han, Sungho et al. (2013) Neuronal activity-regulated pentraxin expressed in medial prefrontal cortex neurons is not necessary for extinction of heroin self-administration. Behav Pharmacol 24:332-6
Reti, Irving M; Blouin, Ashley M; Worley, Paul F et al. (2011) Mediating the effects of drug abuse: the role of Narp in synaptic plasticity. ILAR J 52:321-8
Hodgkinson, Stacy C; Colantuoni, Elizabeth; Roberts, Debra et al. (2010) Depressive symptoms and birth outcomes among pregnant teenagers. J Pediatr Adolesc Gynecol 23:16-22

Showing the most recent 10 out of 11 publications