This application seeks support from the National Institute on Drug Abuse R25 mechanism for pre-doctoral and postdoctoral research positions at the Virginia Institute for Psychiatric and Behavioral Genetics (VIPBG) at Virginia Commonwealth University (VCU). The overall goal of this research education program is to provide an environment that encourages the development and application of statistical genetics at the highest levels. To accomplish this goal, a research education program in statistical genetics will been developed to foster interdisciplinary research, a key tenet of the NIDA mission, and which we believe is essential to conducting research in this field. Two areas of research focus are identified: Advanced Genetic Epidemiology and Statistical Molecular Genetics. These areas are synergistic and address a diverse variety of statistical methods, both those in current use and those under development. The research education program consists of pre-doctoral and postdoctoral components. Pre-doctoral participants will pursue degrees in either Human and Molecular Genetics or Biostatistics. This component is designed to recruit, at the earliest time in their careers, potential future investigators to research in statistical genetics focused on substance use, abuse and dependence (SUAD).
The aim i s to create a cohort of PhD graduates who are have been extensively exposed to, and begun to publish research in, this area at the outset of their research training. The postdoctoral component recognizes that many promising young researchers have training in areas relevant to, but not focused on, the statistical genetics of substance use and abuse. This flexible 2-3 year postdoctoral training component will help guide young investigators to this field of study and will provide them with integrated and focused training that will enable them to pursue careers in statistical genetics of SUAD. Research education is intended for individuals with training in mathematics, statistics, biostatistics, genetics, psychology or pharmacology and to those who have completed their clinical requirements for the MD degree. The goal of the postdoctoral component is to educate independent investigators who will contribute to the efforts to identify and characterize the genetic and environmental determinants of SUAD;they are expected to do so at VCU and at other institutions nationwide. To accomplish the overall program goal we will: i) Offer and carefully monitor a multidisciplinary integrated research training program with a range of research opportunities;ii) Meet the needs for training in emerging research areas in SUAD;iii) Provide training to researchers from diverse academic and ethnic backgrounds and intensive mentoring;iv) Provide a specialized curriculum that will merge strengths in SUAD research at our institution;and v) Disseminate course materials, developed software, user guides and example scripts to the wider community by teaching workshops and establishing a website with web casts, pod casts and script libraries.

Public Health Relevance

This project seeks support from the NIDA R25 research education program in statistical genetics of substance abuse. Two predoctoral and three postdoctoral participants will pursue individualized courses of training in statistical genetics, and participate in active research projects in the Virginia Institute for Psychiatric and Behavioral Genetics at Virginia Commonwealth University.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-MXH-H (16))
Program Officer
Weinberg, Naimah Z
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Virginia Commonwealth University
Schools of Medicine
United States
Zip Code
Savage, Jeanne E; Kaprio, Jaakko; Korhonen, Tellervo et al. (2016) The effects of social anxiety on alcohol and cigarette use across adolescence: Results from a longitudinal twin study in Finland. Psychol Addict Behav 30:462-74
Ware, Jennifer J; Chen, Xiangning; Vink, Jacqueline et al. (2016) Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. Sci Rep 6:20092
Moore, Ashlee A; Neale, Michael C; Silberg, Judy L et al. (2016) Substance Use and Depression Symptomatology: Measurement Invariance of the Beck Depression Inventory (BDI-II) among Non-Users and Frequent-Users of Alcohol, Nicotine and Cannabis. PLoS One 11:e0152118
Verhulst, Brad; Neale, Michael C (2016) Minor Allele Frequency Changes the Nature of Genotype by Environment Interactions. Behav Genet 46:726-33
Clark, Shaunna L; McClay, Joseph L; Adkins, Daniel E et al. (2016) Deep Sequencing of Three Loci Implicated in Large-Scale Genome-Wide Association Study Smoking Meta-Analyses. Nicotine Tob Res 18:626-31
Lubke, Gitta H; Miller, Patrick J; Verhulst, Brad et al. (2016) A powerful phenotype for gene-finding studies derived from trajectory analyses of symptoms of anxiety and depression between age seven and 18. Am J Med Genet B Neuropsychiatr Genet 171:948-57
Clark, Shaunna L; Gillespie, Nathan A; Adkins, Daniel E et al. (2016) Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse. Addict Behav 53:132-40
Kirkpatrick, Robert M; Neale, Michael C (2016) Applying Multivariate Discrete Distributions to Genetically Informative Count Data. Behav Genet 46:252-68
Do, Elizabeth K; Latendresse, Shawn J; Edwards, Alexis C et al. (2016) Associations Between Gestational Age at Birth and Alcohol Use in the Avon Longitudinal Study of Parents and Children. Alcohol Clin Exp Res 40:1328-38
Cooke, Megan E; Nasim, Aashir; Cho, Seung Bin et al. (2016) Predicting Tobacco Use across the First Year of College. Am J Health Behav 40:484-95

Showing the most recent 10 out of 73 publications