The goal of this IMSD Proposal is to increase the number of students in graduate training who contribute to diversity in the biomedical research endeavor and promote their successful completion of the PhD degree. Our focus is upon students who have very strong letters of recommendation in terms of their research talents, but who because of weaker scores (GPA, GRE) might not gain admission into a strong biomedical graduate program. We describe a broad recruiting approach and a rigorous admission strategy. The students are extensively mentored throughout their time in the program to enable them to reach their full potential in a relatively short time period. They take an extensive and thorough didactic course in their first summer, along with a lab course designed to expose them to cutting edge technologies. This has the advantage of making these students highly competitive once they begin their rotations. The students are mentored very closely. This includes meetings with the program faculty for tutoring and advising on a weekly basis. In addition they participate fully in all of our mentoring activities for all first year biomedical graduate students. This includes a weekly IMPACT session wherein small groups of students meet with a faculty member to discuss any and all issues pertaining to graduate education, as well as a weekly FOCUS session wherein a small group of students meet with a faculty member to analyze and discuss a recent paper from the literature. Here the goal is to become entirely comfortable with gaining information from the literature rather than from a textbook. To enhance oral presentation as well as critical thinking skills, students participate in the IMSD journal club each spring. Finally, and in the long run most important, the IMSD students rotate through faculty laboratories as they choose the lab for their thesis research. We provide a performance-based program so that students exit the IMSD program after a one or two year period, depending on individual progress. So far all of our students are in good standing and progressing well, with one exception as a consequence of a serious illness.

Public Health Relevance

This program is dedicated towards an important societal goal, namely increasing the number of UR individuals who enter graduate school to do research in Biomedical Science. We propose to do this by an extensive, creative and carefully mentored step by step process of research and training. The ultimate goal is to increase the number of these individuals in the Biomedical Workforce.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Education Projects (R25)
Project #
Application #
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Janes, Daniel E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Schools of Medicine
United States
Zip Code
Ren, Liping; Willet, Alaina H; Roberts-Galbraith, Rachel H et al. (2015) The Cdc15 and Imp2 SH3 domains cooperatively scaffold a network of proteins that redundantly ensure efficient cell division in fission yeast. Mol Biol Cell 26:256-69
Vickers, Kasey C; Roteta, Leslie A; Hucheson-Dilks, Holli et al. (2015) Mining diverse small RNA species in the deep transcriptome. Trends Biochem Sci 40:7-Apr
Andrews, Omozusi E; Cha, Diana J; Wei, Chunyao et al. (2014) RNAi-mediated gene silencing in zebrafish triggered by convergent transcription. Sci Rep 4:5222
Palmer, Trenis D; Martinez, Carlos H; Vasquez, Catalina et al. (2014) Integrin-free tetraspanin CD151 can inhibit tumor cell motility upon clustering and is a clinical indicator of prostate cancer progression. Cancer Res 74:173-87
Suarez, Sandra; McCollum, Gary W; Bretz, Colin A et al. (2014) Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-?/?. Invest Ophthalmol Vis Sci 55:8232-40
Cleveland, Susan M; Goodings, Charnise; Tripathi, Rati M et al. (2014) LMO2 induces T-cell leukemia with epigenetic deregulation of CD4. Exp Hematol 42:581-93.e5
Pope, Jillian L; Bhat, Ajaz A; Sharma, Ashok et al. (2014) Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling. Gut 63:622-34
Hermanson, Daniel J; Gamble-George, Joyonna C; Marnett, Lawrence J et al. (2014) Substrate-selective COX-2 inhibition as a novel strategy for therapeutic endocannabinoid augmentation. Trends Pharmacol Sci 35:358-67
Irish, Jonathan M; Doxie, Deon B (2014) High-dimensional single-cell cancer biology. Curr Top Microbiol Immunol 377:1-21
Jeff, Janina M; Donahue, Brian S; Brown-Gentry, Kristin et al. (2014) Genetic variation in the *1-adrenergic receptor is associated with the risk of atrial fibrillation after cardiac surgery. Am Heart J 167:101-108.e1

Showing the most recent 10 out of 32 publications