The goal of this IMSD Proposal is to increase the number of students in graduate training who contribute to diversity in the biomedical research endeavor and promote their successful completion of the PhD degree. Our focus is upon students who have very strong letters of recommendation in terms of their research talents, but who because of weaker scores (GPA, GRE) might not gain admission into a strong biomedical graduate program. We describe a broad recruiting approach and a rigorous admission strategy. The students are extensively mentored throughout their time in the program to enable them to reach their full potential in a relatively short time period. They take an extensive and thorough didactic course in their first summer, along with a lab course designed to expose them to cutting edge technologies. This has the advantage of making these students highly competitive once they begin their rotations. The students are mentored very closely. This includes meetings with the program faculty for tutoring and advising on a weekly basis. In addition they participate fully in all of our mentoring activities for all first year biomedical graduate students. This includes a weekly IMPACT session wherein small groups of students meet with a faculty member to discuss any and all issues pertaining to graduate education, as well as a weekly FOCUS session wherein a small group of students meet with a faculty member to analyze and discuss a recent paper from the literature. Here the goal is to become entirely comfortable with gaining information from the literature rather than from a textbook. To enhance oral presentation as well as critical thinking skills, students participate in the IMSD journal club each spring. Finally, and in the long run most important, the IMSD students rotate through faculty laboratories as they choose the lab for their thesis research. We provide a performance-based program so that students exit the IMSD program after a one or two year period, depending on individual progress. So far all of our students are in good standing and progressing well, with one exception as a consequence of a serious illness.

Public Health Relevance

This program is dedicated towards an important societal goal, namely increasing the number of UR individuals who enter graduate school to do research in Biomedical Science. We propose to do this by an extensive, creative and carefully mentored step by step process of research and training. The ultimate goal is to increase the number of these individuals in the Biomedical Workforce.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Education Projects (R25)
Project #
5R25GM062459-10
Application #
8240972
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Janes, Daniel E
Project Start
2000-10-01
Project End
2016-01-31
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
10
Fiscal Year
2012
Total Cost
$683,028
Indirect Cost
$40,448
Name
Vanderbilt University Medical Center
Department
Physiology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Doxie, Deon B; Greenplate, Allison R; Gandelman, Jocelyn S et al. (2018) BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors. Pigment Cell Melanoma Res 31:708-719
Shonesy, Brian C; Parrish, Walker P; Haddad, Hala K et al. (2018) Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior. Biol Psychiatry 84:304-315
Steiner, Bradley D; Eberly, Allison R; Hurst, Melanie N et al. (2018) Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli. J Membr Biol 251:65-74
Lizama, Britney N; Palubinsky, Amy M; McLaughlin, BethAnn (2018) Alterations in the E3 ligases Parkin and CHIP result in unique metabolic signaling defects and mitochondrial quality control issues. Neurochem Int 117:139-155
Infante Lara, Lorena; Fenner, Sabine; Ratcliffe, Steven et al. (2018) Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences. Nucleic Acids Res 46:2218-2233
Elion, David L; Jacobson, Max E; Hicks, Donna J et al. (2018) Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers. Cancer Res 78:6183-6195
Elion, David L; Cook, Rebecca S (2018) Genetic and Phenotypic Diversification of Heterogeneous Tumor Populations. Trends Mol Med 24:655-656
Durbin, Matthew D; Cadar, Adrian G; Chun, Young Wook et al. (2018) Investigating pediatric disorders with induced pluripotent stem cells. Pediatr Res 84:499-508
Kharade, Sujay V; Kurata, Haruto; Bender, Aaron M et al. (2018) Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol 94:926-937
Elmore, Zachary C; Guillen, Rodrigo X; Gould, Kathleen L (2018) The kinase domain of CK1 enzymes contains the localization cue essential for compartmentalized signaling at the spindle pole. Mol Biol Cell 29:1664-1674

Showing the most recent 10 out of 244 publications