ADVANCING THE CULTURE OF PhD LEARNING & SCHOLARSHIP IN BIOLOGY & HEALTH SCIENCES Project Summary: We propose to address the national shortage of underrepresented (UR) groups in science and to build capacity to train and produce UR PhDs in these fields. With emphasis on under-represented minorities (URMs) we will: a) Increase the numbers of U.S. UR students completing PhDs and pursuing science careers, and b) Expand our successful BioMed program to all non-BioMed STEM PhD programs in the university. a) We will strengthen BioMed collaborations where IMSD practices have triggered positive catalytic changes and capitalize on achievements by building new collaborations with institutions similarly committed to broadening STEM participation. IMSD has helped to increase BioMed's UR PhD student (specifically URMs) numbers from ~4% to 19.6%. This population accounts for 66% of all of our URM STEM PhD students. In 2014, as an IMSD outcome, Brown ranked 11th in the nation in producing African-American PhD holders in the biological & biomedical sciences. We will strive for similar milestones for all other UR groups in these fields. b) IMSD's inclusion of 13 non-BioMed STEM PhD programs will be initiated by building a critical mass of UR students in disciplines allied & convergent with the biological public health fields that lead to careers in these fields. We will increase the number of these university students from the current level of ~4.2% to ~15% in 5 years. Trainees will be supported in Applied Math, Chemistry, Cognitive, Linguistics & Psychological Sciences, Computer Science, 4 Engineering PhD programs, Physics and 4 Public Health PhD programs. In transforming the Brown BioMed IMSD Program into the Brown Institutional IMSD Program we will establish Brown as a national leader in producing scientists & scholars. Our maturing program will: ? Increase BioMed's UR graduate student population from our pre-IMSD era low of ~5% to 25%. ? Increase the non-BioMed (university) UR graduate population from its current level of~4.2% to 15%. ? Maximize outreach & support of all future IMSD students and non-IMSD students (the bystander effect) ? Institutionalize IMSD practices so that they are inherited broadly at Brown and at our partner institutions Brown IMSD's objectives will be met by achieving the following specific aims: 1) Expand the reach and impact of the Brown IMSD program through expanded internal and external program partnerships, 2) Build on IMSD's Multi-Faceted, Individualized Educational and Training Programs activities and 3) Broaden IMSD's institutional impact by improving institution-wide diversity practices. In the body of this proposal we provide background, and an assessment of the state of STEM training at Brown and provide a) a plan that will move Brown to the top10 in the nation in producing UR PhDs in all sciences, b) elevate Brown to `first among Ivies' and c) make Brown at attractive destination and inclusive rigorous environment for PhD training. Institutional support is provided by Brown's commitment to support 8 additional URM STEM PhD students to compliment the 14 that will be support by this proposal.

Public Health Relevance

This program which uses a) an innovative approach of constructing academic and social scaffolds around trainees, b) innovatively embraces STEM discipline convergence by supporting interdisciplinary training and c) innovatively unifies training efforts across 4 discrete schools (The Graduate School, The School of Engineering, The School of Medicine and The School of Public Health) will prepare predoctoral scholars to join the U.S. scientific workforce who will advance health and health knowledge.

Agency
National Institute of Health (NIH)
Type
Education Projects (R25)
Project #
2R25GM083270-10
Application #
9209084
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Koduri, Sailaja
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Brown University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Nicholson, Hilary; Mesangeau, Christophe; McCurdy, Christopher R et al. (2016) Sigma-2 Receptors Play a Role in Cellular Metabolism: Stimulation of Glycolytic Hallmarks by CM764 in Human SK-N-SH Neuroblastoma. J Pharmacol Exp Ther 356:232-43
Nunez, Kavin; Kay, Jared; Krotow, Alexander et al. (2016) Cigarette Smoke-Induced Alterations in Frontal White Matter Lipid Profiles Demonstrated by MALDI-Imaging Mass Spectrometry: Relevance to Alzheimer's Disease. J Alzheimers Dis 51:151-63
Chan, Philip A; Towey, Caitlin; Poceta, Joanna et al. (2016) Online Hookup Sites for Meeting Sexual Partners Among Men Who Have Sex with Men in Rhode Island, 2013: A Call for Public Health Action. Public Health Rep 131:264-71
López-Fagundo, Cristina; Livi, Liane L; Ramchal, Talisha et al. (2016) A biomimetic synthetic feeder layer supports the proliferation and self-renewal of mouse embryonic stem cells. Acta Biomater 39:55-64
Brown, Caitlin W; Brodsky, Alexander S; Freiman, Richard N (2015) Notch3 overexpression promotes anoikis resistance in epithelial ovarian cancer via upregulation of COL4A2. Mol Cancer Res 13:78-85
Zabala, Valerie; Tong, Ming; Yu, Rosa et al. (2015) Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease. Alcohol Alcohol 50:118-31
Aninwene 2nd, George E; Abadian, Pegah N; Ravi, Vishnu et al. (2015) Lubricin: a novel means to decrease bacterial adhesion and proliferation. J Biomed Mater Res A 103:451-62
Wilcox, Bethany J; Beckwith, Jonathan G; Greenwald, Richard M et al. (2015) Biomechanics of head impacts associated with diagnosed concussion in female collegiate ice hockey players. J Biomech 48:2201-4
Fernandez, Cristina A; Loucks, Eric B; Arheart, Kristopher L et al. (2015) Evaluating the Effects of Coping Style on Allostatic Load, by Sex: The Jackson Heart Study, 2000-2004. Prev Chronic Dis 12:E165
Nicholson, Hilary; Comeau, Anthony; Mesangeau, Christophe et al. (2015) Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther 354:203-12

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