The Summer Undergraduate Research in Physiology (SURP) program at the University of Michigan (UM), currently funded by the R25HL108842 (?Promoting Diversity of Future Scientists?), is proposed to be extended to another five incoming classes to provide training for underrepresented students to enter advanced graduate programs or pursue careers in biomedical and clinical research. The renewal SURP program includes 25 excellent faculty mentors from 5 basic science and 7 clinical departments within the UM Medical School, who have collectively mentored 114 summer undergraduate trainees, 51 of whom from underrepresented backgrounds. During the past four years, we evaluated 153 applications and enrolled 36 students from across the US. Notably, 91% (21/23) of our SURP trainees who have finished their undergraduate degrees are pursuing advanced graduate degrees, or holding technical positions in academic biomedical research settings or in private sectors. Five of the 36 students have published at least one paper with their research mentors, and at least eight more manuscripts are in progress. The focus of this renewal application is to continue the successful SURP program by recruiting 10 students per summer. Our 12-week summer research program includes (1) fulltime hands-on research experience in laboratories of our faculty mentors, (2) mentoring meetings to ensure that student trainees are taking maximum advantages of all the resources available to them; and (3) end of summer mini-symposium with oral presentations given by the students sharing their research projects. The SURP educational program incorporates a noon lecture series, designed specifically for the summer trainees and presented by faculty members, that teaches important physiology and research- related principles, including the use of different model organisms, ethics in laboratory research, and career opportunities in biomedical sciences. The SURP research education program will continue to be under the oversight of an Internal Advisory Committee, and student selection and progress monitoring accomplished by a Student Selection and Mentoring Committee. As such, we are fully committed to providing training to talented college students, from currently underrepresented backgrounds, to meet the needs of an increasingly diverse population.

Public Health Relevance

The goal of our renewal R25 program is to continue to provide undergraduate students from minority or disadvantaged backgrounds an exciting research experience in cardiovascular, pulmonary or sleep-related physiology at the University of Michigan. Our goal is that this research experience will stimulate the career development of young talented students from diverse backgrounds.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-F (O4))
Program Officer
Scott, Jane
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
Gatti, John R; Zhang, Xiaojie; Korcari, Ejona et al. (2018) Redistribution of Mature Smooth Muscle Markers in Brain Arteries in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy. Transl Stroke Res :
Wang, Michael M; Zhang, Xiaojie; Lee, Soo Jung et al. (2018) Expression of periaxin (PRX) specifically in the human cerebrovascular system: PDZ domain-mediated strengthening of endothelial barrier function. Sci Rep 8:10042
Domingo-Gonzalez, Racquel; Martínez-Colón, Giovanny J; Smith, Alana J et al. (2016) Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2. Am J Respir Crit Care Med 193:186-97
Li, Duan; Mabrouk, Omar S; Liu, Tiecheng et al. (2015) Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest. Proc Natl Acad Sci U S A 112:E2073-82
Domingo-Gonzalez, Racquel; Katz, Samuel; Serezani, C Henrique et al. (2013) Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant. J Immunol 190:5809-17