Alcohol-related disorders are areas of major public health and socio-economic concern.
Research aim ed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol abuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from alcoholic subjects and matched controls. The New South Wales Tissue Resource Center (NSW TRC) at the University of Sydney is an established brain bank that focuses on facilitating research into alcoholism, alcohol-related brain damage and associated conditions. Since its inception the NSW TRC has provided tissue for over 150 research projects.
The aim of this innovative facility is to continue o provide fresh-frozen and formalin fixed tissue to research groups in the USA and worldwide who are studying alcohol use disorders. Tissue is collected, with appropriate consent, from forensic autopsies and through a prospective brain donor program, Using our Brains. The donors have lifestyle, medical and psychiatric histories fully documented. Access is open to any researcher with institutional ethics approval. In addition to providing researchers with tissue, the NSW TRC takes a leading role in the area of brain banking by researching methods for enhancing tissue quality, developing standardized preparation protocols, undertaking meticulous clinical characterization of cases, building better information management systems and training staff. Brain banking is a long-term endeavor and maximum benefits will be seen as the number of researchers accessing the facility increases. Multiple research groups using the same case material and applying different questions or techniques will serve to amplify the outcomes of the research. Furthermore, because of the extensive characterization of cases, research groups can generate data that can be related to clinical, laboratory and radiological information. Taken together the provision of high quality, appropriately prepared tissue to researchers will help address the important health problem caused by alcohol abuse. There is strong support for this facility from both the public and the research community.

Public Health Relevance

Understanding the biological basis of addiction, and the factors affecting an organ's susceptibility to damage, is required to further our knowledge of alcoholism and alcohol toxicity, and for the development of treatment and prevention strategies. Such research is facilitated by access to well-characterized, ethically obtained human post-mortem brain tissue from the NSW Tissue Resource Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects (R28)
Project #
5R28AA012725-15
Application #
8731164
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Reilly, Matthew
Project Start
2000-09-01
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Sydney
Department
Type
DUNS #
City
Sydney
State
Country
Australia
Zip Code
2006
Dennis, C V; Suh, L S; Rodriguez, M L et al. (2016) Human adult neurogenesis across the ages: An immunohistochemical study. Neuropathol Appl Neurobiol 42:621-638
Li, Hongyun; Ruberu, Kalani; Karl, Tim et al. (2016) Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. PLoS One 11:e0148238
Palmer-Aronsten, Beatrix; Sheedy, Donna; McCrossin, Toni et al. (2016) An International Survey of Brain Banking Operation and Characterization Practices. Biopreserv Biobank 14:464-469
McCorkindale, A N; Sheedy, D; Kril, J J et al. (2016) The effects of chronic smoking on the pathology of alcohol-related brain damage. Alcohol 53:35-44
Sutherland, G T; Sheedy, D; Stevens, J et al. (2016) The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research. Alcohol 52:33-9
Sarkisyan, Daniil; Hussain, Muhammad Z; Watanabe, Hiroyuki et al. (2015) Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. Front Cell Neurosci 9:187
Geevasinga, Nimeshan; Menon, Parvathi; Nicholson, Garth A et al. (2015) Cortical Function in Asymptomatic Carriers and Patients With C9orf72 Amyotrophic Lateral Sclerosis. JAMA Neurol 72:1268-74
Farris, S P; Arasappan, D; Hunicke-Smith, S et al. (2015) Transcriptome organization for chronic alcohol abuse in human brain. Mol Psychiatry 20:1438-47
Barry, Guy; Guennewig, Boris; Fung, Samantha et al. (2015) Long Non-Coding RNA Expression during Aging in the Human Subependymal Zone. Front Neurol 6:45
Fatima, Manaal; Tan, Rachel; Halliday, Glenda M et al. (2015) Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways. Acta Neuropathol Commun 3:47

Showing the most recent 10 out of 67 publications