Alcohol-related disorders are areas of major public health and socio-economic concern.
Research aim ed at preventing addiction and organ damage, especially alcohol-related brain damage (ARBD), must be underpinned by a sound knowledge of the biology of alcohol abuse at a cellular level. Such research is dependent on access to high quality, extensively characterized tissue from alcoholic subjects and matched controls. The New South Wales Tissue Resource Center (NSW TRC) at the University of Sydney is an established brain bank that focuses on facilitating research into alcoholism, alcohol-related brain damage and associated conditions. Since its inception the NSW TRC has provided tissue for over 150 research projects.
The aim of this innovative facility is to continue o provide fresh-frozen and formalin fixed tissue to research groups in the USA and worldwide who are studying alcohol use disorders. Tissue is collected, with appropriate consent, from forensic autopsies and through a prospective brain donor program, Using our Brains. The donors have lifestyle, medical and psychiatric histories fully documented. Access is open to any researcher with institutional ethics approval. In addition to providing researchers with tissue, the NSW TRC takes a leading role in the area of brain banking by researching methods for enhancing tissue quality, developing standardized preparation protocols, undertaking meticulous clinical characterization of cases, building better information management systems and training staff. Brain banking is a long-term endeavor and maximum benefits will be seen as the number of researchers accessing the facility increases. Multiple research groups using the same case material and applying different questions or techniques will serve to amplify the outcomes of the research. Furthermore, because of the extensive characterization of cases, research groups can generate data that can be related to clinical, laboratory and radiological information. Taken together the provision of high quality, appropriately prepared tissue to researchers will help address the important health problem caused by alcohol abuse. There is strong support for this facility from both the public and the research community.

Public Health Relevance

Understanding the biological basis of addiction, and the factors affecting an organ's susceptibility to damage, is required to further our knowledge of alcoholism and alcohol toxicity, and for the development of treatment and prevention strategies. Such research is facilitated by access to well-characterized, ethically obtained human post-mortem brain tissue from the NSW Tissue Resource Center.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects (R28)
Project #
5R28AA012725-15
Application #
8731164
Study Section
Special Emphasis Panel (ZAA1)
Program Officer
Reilly, Matthew
Project Start
2000-09-01
Project End
2018-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Sydney
Department
Type
DUNS #
City
Sydney
State
Country
Australia
Zip Code
2006
Hermann, Derik; Hirth, Natalie; Reimold, Matthias et al. (2017) Low ?-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. Neuropsychopharmacology 42:606-614
Hasirci, Ahmet Sait; Maldonado-Devincci, Antoniette M; Beattie, Matthew C et al. (2017) Cellular GABAergic Neuroactive Steroid (3?,5?)-3-Hydroxy-Pregnan-20-One (3?,5?-THP) Immunostaining Levels Are Increased in the Ventral Tegmental Area of Human Alcohol Use Disorder Patients: A Postmortem Study. Alcohol Clin Exp Res 41:299-311
Purves-Tyson, T D; Owens, S J; Rothmond, D A et al. (2017) Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. Transl Psychiatry 7:e1003
Adkins, Amy E; Hack, Laura M; Bigdeli, Tim B et al. (2017) Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Alcohol Clin Exp Res 41:911-928
Hancock, Sarah E; Friedrich, Michael G; Mitchell, Todd W et al. (2017) The phospholipid composition of the human entorhinal cortex remains relatively stable over 80 years of adult aging. Geroscience 39:73-82
Coleman Jr, Leon G; Zou, Jian; Crews, Fulton T (2017) Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J Neuroinflammation 14:22
Warden, Anna; Truitt, Jay; Merriman, Morgan et al. (2016) Localization of PPAR isotypes in the adult mouse and human brain. Sci Rep 6:27618
Corley, Susan M; Tsai, Shan-Yuan; Wilkins, Marc R et al. (2016) Transcriptomic Analysis Shows Decreased Cortical Expression of NR4A1, NR4A2 and RXRB in Schizophrenia and Provides Evidence for Nuclear Receptor Dysregulation. PLoS One 11:e0166944
Sutherland, G T; Sheedy, D; Stevens, J et al. (2016) The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research. Alcohol 52:33-9
McCorkindale, A N; Sheedy, D; Kril, J J et al. (2016) The effects of chronic smoking on the pathology of alcohol-related brain damage. Alcohol 53:35-44

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