China is facing an HIV/AIDS crisis. Although treatment, including free medication, is increasingly available, reports of nonadherence are already surfacing. Within the current window of opportunity, there is an urgent need for research for the development of adherence enhancement programs, which will bolster the efficacy of the medication regimens and thwart the development and transmission of drug resistant virus. The proposed R34 application in response to PAR-03-078 involves a 3-year developmental project to design and pilot a culturally appropriate, clinical feasible, and generalizable program. This project is a multidisciplinary collaboration among experienced investigators at the University of Washington, expert consultants across the U.S., researchers from China's CDC, and care providers at Ditan Hospital in Beijing. The primary aims of the project are to (1) Conduct qualitative research including in-depth interviews and focus groups with patients, their family and caretakers, and providers to determine common barriers and likely facilitators to antiretroviral adherence, which will further guide intervention development; (2) Design a culturally sensitive and theoretically driven adherence program suitable for the Chinese HIV-Positive population, including development of an intervention manual and training materials; (3) Pilot test the program on 10 patients; and (4) After adjustments based on findings from the pilot, implement a preliminary randomized controlled trial (RCT) of 60 patients with 2 arms (minimal vs. enhanced intervention) to assess feasibility and initial efficacy. Although the exact nature of the intervention will depend upon findings from the qualitative phase of the project, research from studies based in the West as well as preliminary work in country suggest the potential acceptability and usefulness of a comprehensive program involving such components as informational group meetings, one-on-one psycho-educational counseling with nurses, DOT provided by family members, alarm reminders, and peer support.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Planning Grant (R34)
Project #
5R34MH074364-03
Application #
7218631
Study Section
Special Emphasis Panel (ZMH1-ERB-C (04))
Program Officer
Stirratt, Michael J
Project Start
2005-04-20
Project End
2010-03-31
Budget Start
2007-04-01
Budget End
2010-03-31
Support Year
3
Fiscal Year
2007
Total Cost
$298,086
Indirect Cost
Name
University of Washington
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wang, Kerong; Chen, Wei-Ti; Zhang, Lin et al. (2016) Facilitators of and barriers to HIV self-management: Perspectives of HIV-positive women in China. Appl Nurs Res 32:91-97
Yang, Joyce P; Xie, Tianyi; Simoni, Jane M et al. (2016) A Mixed-Methods Study Supporting a Model of Chinese Parental HIV Disclosure. AIDS Behav 20:165-73
Yu, Yu; Yang, Joyce P; Shiu, Cheng-Shi et al. (2015) Psychometric testing of the Chinese version of the Medical Outcomes Study Social Support Survey among people living with HIV/AIDS in China. Appl Nurs Res 28:328-33
Yang, Joyce P; Leu, Janxin; Simoni, Jane M et al. (2015) ""Please Don't Make Me Ask for Help"": Implicit Social Support and Mental Health in Chinese Individuals Living with HIV. AIDS Behav 19:1501-9
Chen, Wei-Ti; Shiu, Cheng-Shi; Simoni, Jane M et al. (2013) Challenges of cross-cultural research: lessons from a U.S.-Asia HIV collaboration. Nurs Outlook 61:145-52
Shiu, Cheng-Shi; Chen, Wei-Ti; Simoni, Jane et al. (2013) The Chinese Life-Steps Program: A Cultural Adaptation of a Cognitive-Behavioral Intervention to Enhance HIV Medication Adherence. Cogn Behav Pract 20:202-212
Chen, Wei-Ti; Lee, Shih-Yu; Shiu, Cheng-Shi et al. (2013) Fatigue and sleep disturbance in HIV-positive women: a qualitative and biomedical approach. J Clin Nurs 22:1262-9
Chen, Wei-Ti; Shiu, Cheng-Shi; Yang, Joyce P et al. (2013) Antiretroviral Therapy (ART) Side Effect Impacted on Quality of Life, and Depressive Symptomatology: A Mixed-Method Study. J AIDS Clin Res 4:218
Chen, Wei-Ti; Shiu, Cheng-Shi; Yang, Joyce P et al. (2013) Fatigue and Sleep Disturbance Related to Perceived Stress in Chinese HIV-Positive Individuals: A Mixed Methods Study. J AIDS Clin Res 4:
Rao, D; Chen, W T; Pearson, C R et al. (2012) Social support mediates the relationship between HIV stigma and depression/quality of life among people living with HIV in Beijing, China. Int J STD AIDS 23:481-4

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