Memory impairments and subjectivecomplaints of memory loss are among the most common features of cognitive aging. The long-term goals of this project are to facilitate understanding the effects of aging on memory processes, and to provide a basis for developing techniques and interventions that can enhance memory functions of older adults in their everyday lives. The proposed experiments will contribute to these goals by clarifying the effects of aging on source memory (remembering when and where previous experiences occurred)and false memory (inaccuraterecollections). The first specific aim is to evaluate the hypothesis that older adults can use a """"""""distinctiveness heuristic"""""""" ?a strategy whereby participants demand access to distinctive recollections to support a positive memory decision - to reduce robust false recognition effects that are observed after participants study lists of semantically related words or categorized pictures. Experiments 1-6test this hypothesis by manipulating conditions that do or do not allow participants to rely on a distinctiveness heuristic to reduce false recognition. The second specific aim is to extend the distinctiveness heuristic hypothesis to other forms of false recognition. This objective will be accomplished by examining the effects of distinctive encoding in a paradigm where false memory effects are created by repeating new items on a recognition test (Experiments 7-10), and by testing the hypothesis that younger adults will show greater """"""""false recognition reversal"""""""" than older adults because the effect depends on memory processes that are impaired in older adults, and cannot be produced by invoking a distinctiveness heuristic (Experiment11-13). The third specific aim is to characterize source memory in older adults and examine its role in the generation and suppression of false memories. To do so, we assess the hypothesis that memory for partial source information is preserved in older adults and can provide a basis for using the distinctiveness heuristic (Experiments 14-16), and also evaluate whether older adults can use a likelihood heuristic to reduce source memory errors (Experiment 17). The fourth specific aim ? to evaluate the contribution of conceptual information to age-related increases in false recognition of categorized pictures and novel patterns ?will be accomplished by attempting to interfere with verbal labeling (Experiment 18) and by manipulating the presence or absence of verbal labels for novel visual patterns (Experiment 19). Taken together, the proposed studies will provide new insights into memory distortions that accompany aging and what can be done to minimize them. 3ERFORMANCE SITE(S) (organization, city, state) Harvard University: Cambridge, MA KEY PERSONNEL. See instructions on page 11. Use continuationpages as neededto provide the requiredinformation in the format shown below. Name Organization Role on Project Daniel L. Schacter Harvard University P.I. Chad S.Dodson Harvard University Post-Doctoral Researcher PHS 398(Rev.5/95) Page 2 B B Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. CC Principal Investj^Br/Program Director (Last, first, middle): ^^Bhacter, Daniel L. Type the name of the principal investigator/program direcraPIFthe top of eachprinted pageand each continuation page. (Fortype specifications, see instructions on page 6.) RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description,

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG008441-19
Application #
7390758
Study Section
Special Emphasis Panel (NSS)
Program Officer
Wagster, Molly V
Project Start
1989-08-04
Project End
2010-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
19
Fiscal Year
2008
Total Cost
$371,322
Indirect Cost
Name
Harvard University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Carpenter, Alexis C; Schacter, Daniel L (2018) False memories, false preferences: Flexible retrieval mechanisms supporting successful inference bias novel decisions. J Exp Psychol Gen 147:988-1004
Cao, Xiancai; Madore, Kevin P; Wang, Dahua et al. (2018) Remembering the past and imagining the future: attachment effects on production of episodic details in close relationships. Memory 26:1140-1150
De Brigard, Felipe; Hanna, Eleanor; St Jacques, Peggy L et al. (2018) How thinking about what could have been affects how we feel about what was. Cogn Emot :1-14
Seli, Paul; Ralph, Brandon C W; Konishi, Mahiko et al. (2017) What did you have in mind? Examining the content of intentional and unintentional types of mind wandering. Conscious Cogn 51:149-156
Campbell, Karen L; Schacter, Daniel L (2017) Aging and the Resting State: Is Cognition Obsolete? Lang Cogn Neurosci 32:661-668
Campbell, Karen L; Schacter, Daniel L (2017) Aging and the Resting State: Cognition is not Obsolete. Lang Cogn Neurosci 32:692-694
Jing, Helen G; Madore, Kevin P; Schacter, Daniel L (2017) Preparing for what might happen: An episodic specificity induction impacts the generation of alternative future events. Cognition 169:118-128
Gaesser, Brendan; Dodds, Haley; Schacter, Daniel L (2017) Effects of aging on the relation between episodic simulation and prosocial intentions. Memory 25:1272-1278
De Brigard, Felipe; Brady, Timothy F; Ruzic, Luka et al. (2017) Tracking the emergence of memories: A category-learning paradigm to explore schema-driven recognition. Mem Cognit 45:105-120
Maillet, David; Seli, Paul; Schacter, Daniel L (2017) Mind-wandering and task stimuli: Stimulus-dependent thoughts influence performance on memory tasks and are more often past- versus future-oriented. Conscious Cogn 52:55-67

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