Mental experiences involve active information from various sources (perceptions, imaginations, inferences, memories, emotions). Because there is overlap in the features arising from different sources and the processes that encode, revive, and evaluate features with respect to their source are not perfect, misattributions can occur (perceptual illusions, memory distortions, false memories, confabulations). Our goal is understanding the cognitive processes and conditions that account for true and false episodic (autobiographical) memories: source memory processes that encode features and associate (bind) them into complex memories, and that revive and evaluate them later (i.e., as we make attributions).Our research is guided by the Source Monitoring Framework (SMF), which identifies cognitive processes, types of information (e.g., features), and associated brain correlates that together serve normal source memory and provides a focus for investigating how source memory might be impaired. In particular, our research program is directed at understanding how source monitoring processes are affected by normal aging. Evidence from brain damaged patients and from neuroimaging suggests that prefrontal cortex (PFC) is critical for encoding, reviving, and evaluating memories, and that a critical function of PFC is to modulate activity in other brain regions (e.g., hippocampus, posterior representational areas) involved in memory. Furthermore, there is increasing evidence that age-related changes in function in PFC contribute to age-related declines in episodic memory. Using cognitive behavioral and functional magnetic resonance imaging (fMRI) methods, the proposed project has three main goals: (1) To further characterize age-related differences in the cognitive processes subserving source memory, that is, those processes that affect the quality of encoding, revival, and evaluation of episodic memories;(2) To identify distinct neural bases of specific cognitive functions important for source memory, how they interact, and how they are affected by aging;(3) To further clarify the relation, at both cognitive and neural levels, between objective and subjective measures of source memory and how they change with age.

Public Health Relevance

Among the consequences of normal aging, one of the most distressing is decline in memory. The associated loss of productivity, physical health, and sense of well-being will create an increasing number of critical economic and public health issues as the US population grows disproportionately older.This proposal is directed at understanding the neural mechanisms that underlie changes in memory function with age.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG009253-22
Application #
8306033
Study Section
Special Emphasis Panel (NSS)
Program Officer
Wagster, Molly V
Project Start
1990-08-01
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
22
Fiscal Year
2012
Total Cost
$606,101
Indirect Cost
$239,877
Name
Yale University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
van den Honert, Rebecca N; McCarthy, Gregory; Johnson, Marcia K (2016) Reactivation during encoding supports the later discrimination of similar episodic memories. Hippocampus 26:1168-78
Johnson, Marcia K; Kuhl, Brice A; Mitchell, Karen J et al. (2015) Age-related differences in the neural basis of the subjective vividness of memories: evidence from multivoxel pattern classification. Cogn Affect Behav Neurosci 15:644-61
Johnson, Matthew R; McCarthy, Gregory; Muller, Kathleen A et al. (2015) Electrophysiological Correlates of Refreshing: Event-related Potentials Associated with Directing Reflective Attention to Face, Scene, or Word Representations. J Cogn Neurosci 27:1823-39
Kim, Kyungmi; Johnson, Marcia K (2015) Activity in ventromedial prefrontal cortex during self-related processing: positive subjective value or personal significance? Soc Cogn Affect Neurosci 10:494-500
Kim, Kyungmi; Johnson, Marcia K (2015) Distinct neural networks support the mere ownership effect under different motivational contexts. Soc Neurosci 10:376-90
Sugimori, Eriko; Mitchell, Karen J; Raye, Carol L et al. (2014) Brain mechanisms underlying reality monitoring for heard and imagined words. Psychol Sci 25:403-13
Kim, Kyungmi; Johnson, Marcia K (2014) Extended self: spontaneous activation of medial prefrontal cortex by objects that are 'mine'. Soc Cogn Affect Neurosci 9:1006-12
Ebner, Natalie C; Johnson, Matthew R; Rieckmann, Anna et al. (2013) Processing own-age vs. other-age faces: neuro-behavioral correlates and effects of emotion. Neuroimage 78:363-71
Mitchell, Karen J; Ankudowich, Elizabeth; Durbin, Kelly A et al. (2013) Age-related differences in agenda-driven monitoring of format and task information. Neuropsychologia 51:2427-41
Kim, Kyungmi; Johnson, Marcia K (2012) Extended self: medial prefrontal activity during transient association of self and objects. Soc Cogn Affect Neurosci 7:199-207

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