Hearing, olfactory, and cognitive impairments are common health problems for aging adults. Age-related declines in sensory and cognitive function contribute to decreased quality of life in older adults. The purpose of this 21-yrfollow-study of a population-based cohort is to identify factors contributing to declines in sensory (hearing and olfaction) and cognitive function with aging. Specifically, the aims are to determine if biomarkers of neuroprotection are associated with the incidence of sensory (hearing and olfaction) and cognitive impairments;if these markers or markers of inflammation and atherosclerosis are associated with declines in auditory and cognitive function or olfaction thresholds;if shared risk factors (inflammatory.vascular and neural factors) contribute to the association between sensory disorders and risk of cognitive impairment;and to identify factors contributing to successful aging, measured by sensory and cognitive function. Subjects are participants in the population-based Epidemiology of Hearing Loss Study (EHLS) and were 48-92 years of age at the baseline examination (1993-95). The cohort was re-examined in 1998-2000, 2003-05, and 2009-2010. The proposed examination will use the same standardized protocols for hearing, olfaction, and cognitive testing, cardiovascular measures, and health questionnaires used in the last phase. New measures will include olfaction thresholds and questions about psychological traits. Laboratory analyses for a panel of biomarkers (cystatin-c, brain-derived neurotrophic factor, insulin-like growth factor-1, Cortisol, and aldosterone) will be conducted on stored samples from two time points. Analyses will use the repeated measures available from this longitudinal study to focus on the effects of long-term exposures. Results from this study will contribute to identifying new strategies to slow the declines in hearing, olfactory, and cognitive function with aging. Our multi-system approach will provide important information useful for planning interventions to promote successful sensory and cognitive aging.

Public Health Relevance

As people age, hearing, olfaction and cognitive problems become common. The results of the proposed study will help to identify factors associated with declines in function. This study has the potential to improve healthy aging by identifying factors which may be suitable for early interventions or treatment to slow the aging process and reduce the burden of these disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG011099-21S1
Application #
8846270
Study Section
Special Emphasis Panel (NSS)
Program Officer
Chen, Wen G
Project Start
1993-03-01
Project End
2019-01-31
Budget Start
2014-06-01
Budget End
2015-01-31
Support Year
21
Fiscal Year
2014
Total Cost
$10,000
Indirect Cost
$3,464
Name
University of Wisconsin Madison
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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Schubert, Carla R; Fischer, Mary E; Pinto, A Alex et al. (2016) Odor detection thresholds in a population of older adults. Laryngoscope :
Fischer, Mary E; Cruickshanks, Karen J; Nondahl, David M et al. (2016) Dichotic Digits Test Performance Across the Ages: Results From Two Large Epidemiologic Cohort Studies. Ear Hear :
Schubert, Carla R; Fischer, Mary E; Pinto, A Alex et al. (2016) Sensory Impairments and Risk of Mortality in Older Adults. J Gerontol A Biol Sci Med Sci :
Wichmann, Margarete A; Cruickshanks, Karen J; Carlsson, Cynthia M et al. (2016) NSAID Use and Incident Cognitive Impairment in a Population-based Cohort. Alzheimer Dis Assoc Disord 30:105-12
Cruickshanks, Karen J; Nondahl, David M; Dalton, Dayna S et al. (2015) Smoking, central adiposity, and poor glycemic control increase risk of hearing impairment. J Am Geriatr Soc 63:918-24
Schubert, Carla R; Cruickshanks, Karen J; Fischer, Mary E et al. (2015) Inflammatory and vascular markers and olfactory impairment in older adults. Age Ageing 44:878-82
Dawes, Piers; Emsley, Richard; Cruickshanks, Karen J et al. (2015) Hearing loss and cognition: the role of hearing AIDS, social isolation and depression. PLoS One 10:e0119616
Dawes, Piers; Cruickshanks, Karen J; Fischer, Mary E et al. (2015) Hearing-aid use and long-term health outcomes: Hearing handicap, mental health, social engagement, cognitive function, physical health, and mortality. Int J Audiol 54:838-44
Wichmann, Margarete A; Cruickshanks, Karen J; Carlsson, Cynthia M et al. (2014) Long-term systemic inflammation and cognitive impairment in a population-based cohort. J Am Geriatr Soc 62:1683-91

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