Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI024157-20
Application #
7111229
Study Section
Special Emphasis Panel (NSS)
Program Officer
Rothermel, Annette L
Project Start
1987-04-01
Project End
2012-02-29
Budget Start
2007-03-15
Budget End
2008-02-29
Support Year
20
Fiscal Year
2007
Total Cost
$342,375
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Milam, Ashley A Viehmann; Bartleson, Juliet M; Donermeyer, David L et al. (2018) Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells during an Immune Response. J Immunol 200:3429-3437
Hong, Jinsung; Persaud, Stephen P; Horvath, Stephen et al. (2015) Force-Regulated In Situ TCR-Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells. J Immunol 195:3557-64
Rodriguez, Stephanie N; Jiang, Meizi; Bujo, Hideaki et al. (2015) Self-pMHCII complexes are variably expressed in the thymus and periphery independent of mRNA expression but dependent on the activation state of the APCs. Mol Immunol 63:428-36
Klein, Ludger; Kyewski, Bruno; Allen, Paul M et al. (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 14:377-91
Persaud, Stephen P; Parker, Chelsea R; Lo, Wan-Lin et al. (2014) Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol 15:266-74
Lo, Wan-Lin; Solomon, Benjamin D; Donermeyer, David L et al. (2014) T cell immunodominance is dictated by the positively selecting self-peptide. Elife 3:e01457
Lynch, Jennifer N; Donermeyer, David L; Weber, K Scott et al. (2013) Subtle changes in TCR? CDR1 profoundly increase the sensitivity of CD4 T cells. Mol Immunol 53:283-94
Lo, Wan-Lin; Donermeyer, David L; Allen, Paul M (2012) A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nat Immunol 13:880-7
Hickman-Brecks, Cynthia L; Racz, Jennifer L; Meyer, Debra M et al. (2011) Th17 cells can provide B cell help in autoantibody induced arthritis. J Autoimmun 36:65-75
Weber, K Scott; Hildner, Kai; Murphy, Kenneth M et al. (2010) Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization. J Immunol 185:2836-46

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