The Multiethnic Cohort (MEC) Study was designed to prospectively investigate the relationship of diet an other lifestyle factors to cancer risk in five ethnic groups (African Americans, Japanese Americans, Latinos Native Hawaiians and Caucasians),and to explore interactions between these risk factors and geneti susceptibility to cancer. Since establishment of the cohort in 1993-96, more than 10 years of follow-up hav accrued on the 215,000 participants, bringing the project to a point where its full potential can now b realized. In the current cycle of support, we are re-administering the baseline questionnaire to obtai updated (10-year) dietary and other information on the subjects (e.g., smoking, physical activity, hormona usage, medications, intercurrent illnesses). We have been analyzing data from the baseline questionnaire both dietary and non-dietary, as well as data on genetic susceptibility and gene-environment interactions Altogether, we have published 50 papers from the cohort since early 2003. We have been among the mos active participants in NCI's Breast and Prostate Cancer Cohort Consortium, and have shared our data wit other members of the consortium, as well as with investigators at outside institutions. For the next 5-yea period, we have several dietary scientific aims, including further research into the basis for ethni differences we observed in diet and cancer relationships, investigation of hypotheses related to dietar constituents recently added to our food composition table (e.g., trans fatty acids, heme iron, glycemic load heterocyclic amines), study of some less common sites (e.g., non-Hodgkin's lymphoma, ovary and kidney) more in-depth subgroup analyses (e.g., by histology and stage), and investigations of the relationship of die to cancer survival. We also have several non-dietary scientific aims, particularly related to investigating as yet unexplainable ethnic differences in breast and lung cancer risk. The important work necessary t maintain the cohort and its several databases will continue, including administration of another short follow up questionnaire and regular enhancements to the unique food composition table. Finally, we will continu to train graduate students and postdoctoral fellows. We expect this research not only to expand knowledg of the role of environmental risk factors and genes in cancer risk, but also to further an understanding of th basis for ethnic/racial disparities in cancer occurrence and survival.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Method to Extend Research in Time (MERIT) Award (R37)
Project #
Application #
Study Section
Special Emphasis Panel (NSS)
Program Officer
Mahabir, Somdat
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Hawaii
Organized Research Units
United States
Zip Code
Leo, Q J N; Ollberding, N J; Wilkens, L R et al. (2016) Nutritional factors and non-Hodgkin lymphoma survival in an ethnically diverse population: the Multiethnic Cohort. Eur J Clin Nutr 70:41-6
Petridis, Christos; Brook, Mark N; Shah, Vandna et al. (2016) Genetic predisposition to ductal carcinoma in situ of the breast. Breast Cancer Res 18:22
Park, Sungshim L; Tiirikainen, Maarit I; Patel, Yesha M et al. (2016) Genetic determinants of CYP2A6 activity across racial/ethnic groups with different risks of lung cancer and effect on their smoking intensity. Carcinogenesis 37:269-79
Maskarinec, G; Morimoto, Y; Jacobs, S et al. (2016) Ethnic admixture affects diabetes risk in native Hawaiians: the Multiethnic Cohort. Eur J Clin Nutr 70:1022-7
Vigen, Cheryl; Kwan, Marilyn L; John, Esther M et al. (2016) Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC). Cancer Causes Control 27:391-401
(2016) No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol 141:386-401
Garcia-Albeniz, Xabier; Rudolph, Anja; Hutter, Carolyn et al. (2016) CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk. Br J Cancer 114:221-9
Travis, Ruth C; Appleby, Paul N; Martin, Richard M et al. (2016) A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk. Cancer Res 76:2288-300
Sposto, Richard; Keegan, Theresa H M; Vigen, Cheryl et al. (2016) The Effect of Patient and Contextual Characteristics on Racial/Ethnic Disparity in Breast Cancer Mortality. Cancer Epidemiol Biomarkers Prev 25:1064-72
Zanetti, Krista A; Wang, Zhaoming; Aldrich, Melinda et al. (2016) Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population. Lung Cancer 98:33-42

Showing the most recent 10 out of 381 publications