Orthognathic surgery now makes it possible to correct dental and facial deformities that previously could not be treated. The goal of this continuing project is to evaluate the morphologic, clinical, technical and physiologic response factors that determine stability of results from this surgical-orthodontic treatment. Utilizing existing computer data base information from the first phases of this project along with data from new patients, we will test specific hypotheses to explore the relationships of the patient's original dentofacial deformity and clinical treatment procedures to physiologic adaptation and morphologic stability followng treatment. In the present project period, emphasis will be placed on documenting long term (5 year) stability or morphologic changes; further exploration of the relationship between the physiologic variables of lip pressure, nasal resistance and respiratory mode to morphologic stability or relapse tendencies; tests of association between mode to morphologic stability or relapse tendencies; tests of association between clinical variables (direction and nagnitude of jaw movement, graft material, type of incision, etc.) and morphologic stability; clarifying the effects of various orthognathic surgery procedures on jaw function and indicated by temporomandibular joint adaptation and by occlusal force magnitude and direction; evaluating the effects of rigid fixation with screws and/or small bone plates on short and long term stability; and testing the hypothesis that relocating the chin (genioplasty) via lower border osteotomy significantly alters the balance between tongue and lip pressures across the lower incisors and thereby changes the stable position of these teeth. Research of this type to clarify physiologic adaptation and morphologic stability following surgery is important to improve furture treatment. The data also can provide a better understanding of the etiology of facial deformity problems by illustrating the effect of changes in humans.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DE005215-12
Application #
3482817
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1979-01-01
Project End
1992-12-31
Budget Start
1990-01-01
Budget End
1990-12-31
Support Year
12
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
Schools of Dentistry
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Brookes, Carolyn Dicus; Golden, Brent A; Lawrence, Scott D et al. (2015) Unilateral mydriasis after maxillary osteotomy: a case series and review of the literature. J Oral Maxillofac Surg 73:1159-68
Magraw, Caitlin B L; Garaas, Rachel; Shaw, Alan et al. (2015) Changes in scleral exposure following modified Le Fort III osteotomy. Oral Surg Oral Med Oral Pathol Oral Radiol 120:119-24.e1
Proffit, William R; Jackson, Tate H; Turvey, Timothy A (2013) Changes in the pattern of patients receiving surgical-orthodontic treatment. Am J Orthod Dentofacial Orthop 143:793-8
Cevidanes, Lucia H S; Alhadidi, Abeer; Paniagua, Beatriz et al. (2011) Three-dimensional quantification of mandibular asymmetry through cone-beam computerized tomography. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:757-70
Nguyen, Tung; Cevidanes, Lucia; Cornelis, Marie A et al. (2011) Three-dimensional assessment of maxillary changes associated with bone anchored maxillary protraction. Am J Orthod Dentofacial Orthop 140:790-8
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Phillips, C; Essick, G (2011) Inferior alveolar nerve injury following orthognathic surgery: a review of assessment issues. J Oral Rehabil 38:547-54
Paniagua, Beatriz; Cevidanes, Lucia; Walker, David et al. (2011) Clinical application of SPHARM-PDM to quantify temporomandibular joint osteoarthritis. Comput Med Imaging Graph 35:345-52
Almeida, R C; Cevidanes, L H S; Carvalho, F A R et al. (2011) Soft tissue response to mandibular advancement using 3D CBCT scanning. Int J Oral Maxillofac Surg 40:353-9
Baccetti, T; De Clerck, H J; Cevidanes, L H et al. (2011) Morphometric analysis of treatment effects of bone-anchored maxillary protraction in growing Class III patients. Eur J Orthod 33:121-5

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