Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK017238-23
Application #
2137060
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Sha, L; Linden, D R; Farrugia, G et al. (2014) Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle. J Physiol 592:1077-89
Farrugia, Gianrico; Szurszewski, Joseph H (2014) Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. Gastroenterology 147:303-13
Sha, Lei; Linden, David R; Farrugia, Gianrico et al. (2013) Hydrogen sulfide selectively potentiates central preganglionic fast nicotinic synaptic input in mouse superior mesenteric ganglion. J Neurosci 33:12638-46
Linden, D R; Furne, J; Stoltz, G J et al. (2012) Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS. Br J Pharmacol 165:2178-90
Strege, Peter R; Bernard, Cheryl E; Kraichely, Robert E et al. (2011) Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5. Am J Physiol Gastrointest Liver Physiol 300:G1105-14
Linden, David R; Levitt, Michael D; Farrugia, Gianrico et al. (2010) Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxid Redox Signal 12:1135-46
Matsuda, Nilce Mitiko; Miller, Steven M; Szurszewski, Joseph H (2010) Heme-oxygenase-2 immunolabelling in pig jejunum. Acta Histochem 112:402-6
Sha, L; Farrugia, G; Linden, D R et al. (2010) The transwall gradient across the mouse colonic circular muscle layer is carbon monoxide dependent. FASEB J 24:3840-9
Ueda, Kazuo; Valdivia, Carmen; Medeiros-Domingo, Argelia et al. (2008) Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Proc Natl Acad Sci U S A 105:9355-60
Mazzone, Amelia; Farrugia, Gianrico (2007) Evolving concepts in the cellular control of gastrointestinal motility: neurogastroenterology and enteric sciences. Gastroenterol Clin North Am 36:499-513, vii

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