Program Director/Principal Investigator (Last, First, Middle): M c M a h o n , A n d r e w PROJECT SUMMA,RY (See instotctions): The mammalian kidney has a rich history of embryological study, its physiological actions are well understood and kidney disease is one of the leading health care issues. For these and other reasons (for example the (dynamic cellular events intrinsic to the kidney program), we have chosen to focus on this system. As we wish to relate our findings as directly as possible to the clinic, the mouse is our rnodel. Combining genetic, genomic and biochemical strategies, the proposed research will define and mechanistically dissect key regulatory processes in the developing mammalian kidney.
Our goal is do determine how nephron generating stem cells are regulated to enable new approaches to treat kidney disease.
|O'Brien, Lori L; Guo, Qiuyu; Lee, YoungJin et al. (2016) Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development 143:595-608|
|Li, Joan; Ariunbold, Usukhbayar; Suhaimi, Norseha et al. (2015) Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity. J Am Soc Nephrol 26:81-94|
|Little, Melissa H; Brown, Dennis; Humphreys, Benjamin D et al. (2014) Defining kidney biology to understand renal disease. Clin J Am Soc Nephrol 9:809-11|
|O'Brien, Lori L; McMahon, Andrew P (2014) Induction and patterning of the metanephric nephron. Semin Cell Dev Biol 36:31-8|
|Kobayashi, Akio; Mugford, Joshua W; Krautzberger, A Michaela et al. (2014) Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports 3:650-62|
|Kumar, Sanjeev; Liu, Jing; McMahon, Andrew P (2014) Defining the acute kidney injury and repair transcriptome. Semin Nephrol 34:404-17|
|Mae, Shin-Ichi; Shono, Akemi; Shiota, Fumihiko et al. (2013) Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun 4:1367|
|Zhang, Xiaoxiao; Peterson, Kevin A; Liu, X Shirley et al. (2013) Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells 31:2667-79|
|DiRocco, Derek P; Kobayashi, Akio; Taketo, Makoto M et al. (2013) Wnt4/Î²-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 24:1399-412|
|Humphreys, Benjamin D; Xu, Fengfeng; Sabbisetti, Venkata et al. (2013) Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest 123:4023-35|
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