Program Director/Principal Investigator (Last, First, Middle): M c M a h o n , A n d r e w PROJECT SUMMA,RY (See instotctions): The mammalian kidney has a rich history of embryological study, its physiological actions are well understood and kidney disease is one of the leading health care issues. For these and other reasons (for example the (dynamic cellular events intrinsic to the kidney program), we have chosen to focus on this system. As we wish to relate our findings as directly as possible to the clinic, the mouse is our rnodel. Combining genetic, genomic and biochemical strategies, the proposed research will define and mechanistically dissect key regulatory processes in the developing mammalian kidney.

Public Health Relevance

Our goal is do determine how nephron generating stem cells are regulated to enable new approaches to treat kidney disease.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Method to Extend Research in Time (MERIT) Award (R37)
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Hoshizaki, Deborah K
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University of Southern California
Other Basic Sciences
Schools of Medicine
Los Angeles
United States
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Oxburgh, Leif; Carroll, Thomas J; Cleaver, Ondine et al. (2017) (Re)Building a Kidney. J Am Soc Nephrol 28:1370-1378
Naiman, Natalie; Fujioka, Kaoru; Fujino, Mari et al. (2017) Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell 41:349-365.e3
O'Brien, Lori L; Guo, Qiuyu; Lee, YoungJin et al. (2016) Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development 143:595-608
Li, Joan; Ariunbold, Usukhbayar; Suhaimi, Norseha et al. (2015) Collecting duct-derived cells display mesenchymal stem cell properties and retain selective in vitro and in vivo epithelial capacity. J Am Soc Nephrol 26:81-94
Kobayashi, Akio; Mugford, Joshua W; Krautzberger, A Michaela et al. (2014) Identification of a multipotent self-renewing stromal progenitor population during mammalian kidney organogenesis. Stem Cell Reports 3:650-62
Short, Kieran M; Combes, Alexander N; Lefevre, James et al. (2014) Global quantification of tissue dynamics in the developing mouse kidney. Dev Cell 29:188-202
Kumar, Sanjeev; Liu, Jing; McMahon, Andrew P (2014) Defining the acute kidney injury and repair transcriptome. Semin Nephrol 34:404-17
Little, Melissa H; Brown, Dennis; Humphreys, Benjamin D et al. (2014) Defining kidney biology to understand renal disease. Clin J Am Soc Nephrol 9:809-11
O'Brien, Lori L; McMahon, Andrew P (2014) Induction and patterning of the metanephric nephron. Semin Cell Dev Biol 36:31-8
O'Brien, Lori L; McMahon, Andrew P (2013) Progenitor programming in mammalian nephrogenesis. Nephrology (Carlton) 18:177-9

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