Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM018325-26
Application #
2173221
Study Section
Special Emphasis Panel (NSS)
Project Start
1980-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
26
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Lewis Jr, Charles A; Shen, Lin; Yang, Weitao et al. (2017) Three Pyrimidine Decarboxylations in the Absence of a Catalyst. Biochemistry 56:1498-1503
Lewis Jr, Charles A; Crayle, Jesse; Zhou, Shuntai et al. (2016) Cytosine deamination and the precipitous decline of spontaneous mutation during Earth's history. Proc Natl Acad Sci U S A 113:8194-9
Carter Jr, Charles W; Wolfenden, Richard (2016) tRNA acceptor-stem and anticodon bases embed separate features of amino acid chemistry. RNA Biol 13:145-51
Wolfenden, Richard; Lewis Jr, Charles A; Yuan, Yang et al. (2015) Temperature dependence of amino acid hydrophobicities. Proc Natl Acad Sci U S A 112:7484-8
Carter Jr, Charles W; Wolfenden, Richard (2015) tRNA acceptor stem and anticodon bases form independent codes related to protein folding. Proc Natl Acad Sci U S A 112:7489-94
Wolfenden, Richard (2014) Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes. J Biol Chem 289:30198-204
Lewis Jr, Charles A; Wolfenden, Richard (2014) The nonenzymatic decomposition of guanidines and amidines. J Am Chem Soc 136:130-6
Zhou, Xin; Chou, Tsui-Fen; Aubol, Brandon E et al. (2013) Kinetic mechanism of human histidine triad nucleotide binding protein 1. Biochemistry 52:3588-600
Lohman, Danielle C; Edwards, David R; Wolfenden, Richard (2013) Catalysis by desolvation: the catalytic prowess of SAM-dependent halide-alkylating enzymes. J Am Chem Soc 135:14473-5
Schroeder, Gottfried K; Zhou, Li; Snider, Mark J et al. (2012) Flight of a cytidine deaminase complex with an imperfect transition state analogue inhibitor: mass spectrometric evidence for the presence of a trapped water molecule. Biochemistry 51:6476-86

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