Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM047434-11
Application #
6197865
Study Section
Special Emphasis Panel (NSS)
Program Officer
Deatherage, James F
Project Start
1992-04-01
Project End
2002-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
11
Fiscal Year
2001
Total Cost
$570,250
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Harms, M B; Ori-McKenney, K M; Scoto, M et al. (2012) Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy. Neurology 78:1714-20
Vallee, Richard B; McKenney, Richard J; Ori-McKenney, Kassandra M (2012) Multiple modes of cytoplasmic dynein regulation. Nat Cell Biol 14:224-30
Hook, Peter; Vallee, Richard (2012) Dynein dynamics. Nat Struct Mol Biol 19:467-9
Ori-McKenney, Kassandra M; Vallee, Richard B (2011) Neuronal migration defects in the Loa dynein mutant mouse. Neural Dev 6:26
Yi, Julie Y; Ori-McKenney, Kassandra M; McKenney, Richard J et al. (2011) High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport. J Cell Biol 195:193-201
Tsai, Jin-Wu; Vallee, Richard B (2011) Live microscopy of neural stem cell migration in brain slices. Methods Mol Biol 750:131-42
Tan, Serena C; Scherer, Julian; Vallee, Richard B (2011) Recruitment of dynein to late endosomes and lysosomes through light intermediate chains. Mol Biol Cell 22:467-77
McKenney, Richard J; Weil, Sarah J; Scherer, Julian et al. (2011) Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. J Biol Chem 286:39615-22
McKenney, Richard J; Vershinin, Michael; Kunwar, Ambarish et al. (2010) LIS1 and NudE induce a persistent dynein force-producing state. Cell 141:304-14
Mao, Yinghui; Varma, Dileep; Vallee, Richard (2010) Emerging functions of force-producing kinetochore motors. Cell Cycle 9:715-9

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