Nearly every form of cardiac disease involves changes to the myocardial stiffness. Current clinically-viable measurement techniques to assess myocardial stiffness are ei- ther invasive and/or involve image-derived metrics. We propose the use of a new imaging method, called Acoustic Radiation Force Impulse (ARFI) imaging, in measuring the me- chanical properties of myocardial tissue. The technique employs ultrasonic radiation force to displace tissue. Conventional ultrasound is then used to observe the response of the tissue to the force. We present preliminary data showing the success of this technique in imaging the changes in stiffness that occur under normal myocardial function. We pro- pose to further develop the ARFI imaging technique and then investigate the use of ARFI imaging in detecting abnormal heart function using animal models. In addition, we pro- pose human clinical studies with pediatric cardiac transplant patients. These studies will evaluate the potential of ARFI imaging to provide early detection of transplant rejection, in grading the severity of heart failure, and in distinguishing between systolic and diastolic heart failure.

Public Health Relevance

Diseases of the heart often involve changes in the stiffness of the heart. We have developed a new imaging method that displays the stiffness of heart tissue. We propose animal and human studies to determine the potential of this method to reliably detect and predict cardiac diseases.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL096023-04
Application #
8241921
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Buxton, Denis B
Project Start
2009-05-15
Project End
2014-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
4
Fiscal Year
2012
Total Cost
$604,197
Indirect Cost
$216,891
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Vejdani-Jahromi, Maryam; Freedman, Jenna; Nagle, Matthew et al. (2016) Quantifying Myocardial Contractility Changes Using Ultrasound-Based Shear Wave Elastography. J Am Soc Echocardiogr :
Vejdani-Jahromi, Maryam; Nagle, Mathew; Jiang, Yang et al. (2016) A Comparison of Acoustic Radiation Force-Derived Indices of Cardiac Function in the Langendorff Perfused Rabbit Heart. IEEE Trans Ultrason Ferroelectr Freq Control 63:1288-95
Hollender, Peter J; Rosenzweig, Stephen J; Nightingale, Kathryn R et al. (2015) Single- and multiple-track-location shear wave and acoustic radiation force impulse imaging: matched comparison of contrast, contrast-to-noise ratio and resolution. Ultrasound Med Biol 41:1043-57
Vejdani-Jahromi, Maryam; Nagle, Matt; Trahey, Gregg E et al. (2015) Ultrasound shear wave elasticity imaging quantifies coronary perfusion pressure effect on cardiac compliance. IEEE Trans Med Imaging 34:465-73
Hollender, Peter; Bottenus, Nick; Trahey, Gregg (2015) A multiresolution approach to shear wave image reconstruction. IEEE Trans Ultrason Ferroelectr Freq Control 62:1429-39
Eyerly, Stephanie A; Vejdani-Jahromi, Maryam; Dumont, Douglas M et al. (2015) The Evolution of Tissue Stiffness at Radiofrequency Ablation Sites During Lesion Formation and in the Peri-Ablation Period. J Cardiovasc Electrophysiol :
Doherty, Joshua R; Dahl, Jeremy J; Kranz, Peter G et al. (2015) Comparison of Acoustic Radiation Force Impulse Imaging Derived Carotid Plaque Stiffness With Spatially Registered MRI Determined Composition. IEEE Trans Med Imaging 34:2354-65
Pinton, Gianmarco; Trahey, Gregg; Dahl, Jeremy (2014) Spatial coherence in human tissue: implications for imaging and measurement. IEEE Trans Ultrason Ferroelectr Freq Control 61:1976-87
Bahnson, Tristram D; Eyerly, Stephanie A; Hollender, Peter J et al. (2014) Feasibility of near real-time lesion assessment during radiofrequency catheter ablation in humans using acoustic radiation force impulse imaging. J Cardiovasc Electrophysiol 25:1275-83
Byram, Brett; Jakovljevic, Marko (2014) Ultrasonic multipath and beamforming clutter reduction: a chirp model approach. IEEE Trans Ultrason Ferroelectr Freq Control 61:428-40

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