This MERIT extension application builds on the Pi's major findings during the prior funding period to extend prior themes. A major conclusion, consistent with emerging literature is that different functional brain networks Identified through independent component analysis (ICA) of BOLD activation associated with a variety of functional MRI paradigms are commonly engaged across many tasks, In controls and schizophrenia patients. These include networks subserving complex focused attention, "brain idling" (in the resting state and default mode), working memory/executive decision-making, set maintenance and language. These circuits are focused around four major neural nodes, and using approaches such as functional network connectivity, (FNC) one can demonstrate disrupted relationships among these circuits in schizophrenia that seem to plausibly constitute the neural basis of "disconnectivity." We capitalize on our continuing focus on heteromodal association cortical regions as well as continuing to study functional MRI tasks based around semantic knowledge and "Theory of Mind "that we hypothesize are central to schizophrenia formal thought disorder, but have not been explored in depth using the analytic tools available to our group. Finally we will combine the use of functional and anatomical connectivity analysis techniques, singly and in combination, (the latter using fusion techniques across imaging modalities, including novel combinations of Diffusion Tensor Imaging with fMRI), to elucidate relationships between cognitive system dysfunction leading to symptoms and neural network abnormalities.

Public Health Relevance

Schizophrenia is a common, disabling brain-based disorder commonly hypothesized to be due to disconnection between different brain regions, although this has not been demonstrated directly. This proposal seeks to elucidate the nature of the disconnection by examining connections among different brain circuits, using structural and functional MRI and diffusion tensor imaging.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Method to Extend Research in Time (MERIT) Award (R37)
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Special Emphasis Panel (NSS)
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Rumsey, Judith M
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Hartford Hospital
United States
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Pearlson, Godfrey D; Ford, Judith M (2014) Distinguishing between schizophrenia and other psychotic disorders. Schizophr Bull 40:501-3
Hahamy, Avital; Calhoun, Vince; Pearlson, Godfrey et al. (2014) Save the global: global signal connectivity as a tool for studying clinical populations with functional magnetic resonance imaging. Brain Connect 4:395-403
Yang, Genevieve J; Murray, John D; Repovs, Grega et al. (2014) Altered global brain signal in schizophrenia. Proc Natl Acad Sci U S A 111:7438-43
Anticevic, Alan; Yang, Genevieve; Savic, Aleksandar et al. (2014) Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. Schizophr Bull 40:1227-43
Rosenfeld, Ethan S; Pearlson, Godfrey D; Sweeney, John A et al. (2014) Prolonged hemodynamic response during incidental facial emotion processing in inter-episode bipolar I disorder. Brain Imaging Behav 8:73-86
Yu, Qingbao; Sui, Jing; Liu, Jingyu et al. (2013) Disrupted correlation between low frequency power and connectivity strength of resting state brain networks in schizophrenia. Schizophr Res 143:165-71
Jamadar, Sharna; Powers, Natalie R; Meda, Shashwath A et al. (2013) Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study. Brain Imaging Behav 7:15-27
Jamadar, Sharna; O'Neil, Kasey M; Pearlson, Godfrey D et al. (2013) Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder. Biol Psychiatry 73:555-64
Khadka, Sabin; Meda, Shashwath A; Stevens, Michael C et al. (2013) Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry 74:458-66
Jamadar, Sharna D; Pearlson, Godfrey D; O'Neil, Kasey M et al. (2013) Semantic association fMRI impairments represent a potential schizophrenia biomarker. Schizophr Res 145:20-6

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