Neuropsychological, neuroimaging and electrophysiological research supports a crucial role of lateral prefrontal cortex (PFC) in executive control of human behavior. Altered PFC function underlies a host of debilitating developmental, neurological and psychiatric disorders. Despite significant progress in PFC research, the real-time processes supporting PFC control of human cognition remain undetermined. We propose that PFC uses oscillatory dynamics to implement cognitive control of task-dependent neural networks. To address this hypothesis we employ a unique combination of direct cortical recording in neurosurgical patients (Electrocorticography;ECoG) with superb spatio-temporal resolution and signal-to-noise ratio, along with cutting-edge analysis to define PFC-dependent neural networks supporting cognition. We will examine three tasks probing hallmarks of frontal lobe function (categorical perception, working memory and controlled vs. automatic attention) across three sensory modalities (audition, vision, touch) to address the generalizabilty of PFC dependent oscillatory network control. We will then examine the causality of the oscillatory dynamics observed with ECoG using scalp EEG and behavioral methods in patients with focal lesions centered in lateral PFC regions activated in ECoG recording.
Aim 1 will use ECoG recording to define the role of PFC control of phase locking of low frequency neural oscillations between local modules of task dependent networks and examines whether phase locking and cross frequency coupling (CFC) between high gamma oscillations (60-200 Hz) and low frequency oscillations tracks task performance at the single- trial level.
Aim 2 examines the causality of ECoG defined oscillatory processes in patients with focal lateral PFC or posterior parietal cortex (PPC) damage. Finally, we predict that deficits in neural oscillations in the lesioned hemisphere will predict behavioral deficits and that neural oscillations in the non lesioned hemisphere will reveal novel patterns of neuroplasiticity and behavioral compensation. In summary, the proposed work aims to define the role of PFC in both distributed and local network function in the support of human behavior with implications for understanding normal as well as disordered brain function.

Public Health Relevance

This research is relevant to public health because it aims to delineate the mechanisms of PFC control of human behavior. It is well established that a host of disabling neurological, developmental and psychiatric conditions are linked to prefrontal dysfunction. This proposal aims to provide basic information on the role of prefrontal cortex in network control of behavior. This work is essential to the NIH mission since it will provide novel insights into the neurophysiology of prefrontal control of cognition relevant to both normal brain functioning as well as the understanding, diagnosis and treatment of many devastating clinical disorders. !! -1-

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37NS021135-26A1
Application #
8578001
Study Section
Special Emphasis Panel (SPC)
Program Officer
Babcock, Debra J
Project Start
1985-09-09
Project End
2017-06-30
Budget Start
2013-09-01
Budget End
2014-06-30
Support Year
26
Fiscal Year
2013
Total Cost
$448,911
Indirect Cost
$162,067
Name
University of California Berkeley
Department
Neurosciences
Type
Organized Research Units
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Schalk, Gerwin; Marple, Joshua; Knight, Robert T et al. (2017) Instantaneous voltage as an alternative to power- and phase-based interpretation of oscillatory brain activity. Neuroimage 157:545-554
Holdgraf, Christopher R; Rieger, Jochem W; Micheli, Cristiano et al. (2017) Encoding and Decoding Models in Cognitive Electrophysiology. Front Syst Neurosci 11:61
Zheng, Jie; Anderson, Kristopher L; Leal, Stephanie L et al. (2017) Amygdala-hippocampal dynamics during salient information processing. Nat Commun 8:14413
Helfrich, Randolph F; Huang, Melody; Wilson, Guy et al. (2017) Prefrontal cortex modulates posterior alpha oscillations during top-down guided visual perception. Proc Natl Acad Sci U S A 114:9457-9462
Ri├Ęs, Stephanie K; Dhillon, Rummit K; Clarke, Alex et al. (2017) Spatiotemporal dynamics of word retrieval in speech production revealed by cortical high-frequency band activity. Proc Natl Acad Sci U S A 114:E4530-E4538
Johnson, Elizabeth L; Dewar, Callum D; Solbakk, Anne-Kristin et al. (2017) Bidirectional Frontoparietal Oscillatory Systems Support Working Memory. Curr Biol 27:1829-1835.e4
Jafarpour, Anna; Piai, Vitoria; Lin, Jack J et al. (2017) Human hippocampal pre-activation predicts behavior. Sci Rep 7:5959
Odegaard, Brian; Knight, Robert T; Lau, Hakwan (2017) Should a Few Null Findings Falsify Prefrontal Theories of Conscious Perception? J Neurosci 37:9593-9602
Perry, Anat; Saunders, Samantha N; Stiso, Jennifer et al. (2017) Effects of prefrontal cortex damage on emotion understanding: EEG and behavioural evidence. Brain 140:1086-1099
Perry, Anat; Stiso, Jennifer; Chang, Edward F et al. (2017) Mirroring in the Human Brain: Deciphering the Spatial-Temporal Patterns of the Human Mirror Neuron System. Cereb Cortex :

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