Next generation neural probe technology must enable neuroscientists to bridge the gap between neurons and neuronal pools to fully understand the orchestrated 'temporal dynamics'of the brain. This will require high-density, stable recordings in longitudinal experiments. Similarly, next generation brain machine interfaces (BMI) must improve longevity and reliability of the recorded neural signals if translation of the research technology to the clinical realm is to be successful. Long-term signal degradation is widely believed to be directly related to cellular reactivity in the presence of the neural probe. The sub-cellular edge electrode array (or """"""""SEE"""""""" probe) was designed to mitigate the cellular reactivity evident in conventional microelectrode designs and thereby address the longevity and stability issues of recording technology. The SEE design concept hypothesized that if a structural feature size is smaller than a reactive cell body (<7 The primary objective of the proposed work is to develop and validate a microelectrode technology that has shown great promise in improving biocompatibility. This work will microfabricate a novel biomimetic design, the """"""""sub-cellular edge electrode"""""""" array, and provide subsequent long-term validation in animal studies. Animal studies are expected to show improved electrophysiological recording quality, stability, and longevity. Such microelectrode technology will enable neuroscientists and clinicians to achieve long-term sensing in the brain, which would greatly improve our understanding of healthy brain function and offer new opportunities for those suffering from neurological disorders such as spinal cord injury, epilepsy, or ALS.Public Health Relevance
