Novel inhibitors of BK polyomavirus (BKPyV) are urgently needed to prevent the occurrence of virus-induced nephropathy, allograft failure and hemorrhagic cystitis following transplantation. The objective of this Phase I SBIR feasibility study is to identify drug-like compounds that specifically inhibit BKPyV replication. During the course of this Phase I funding period, we will execute a hit finding campaign with a library of 100,000 compounds with optimal drug-like properties. Quality hits that emerge from the assay will be subjected to follow-on testing that will investigate the potency, selectivity, and mechanism of action. The most interesting of these compounds will be subjected to medicinal chemistry driven hit-to-lead efforts to explore structure-activity relationships (SAR). The overall goal of this project is to discover one or more novel lead series, which is defined as a chemotype inhibitor that demonstrates tractable SAR, potent antiviral activity against the available BKPyV strains and minimal cytotoxicity. Success in these endeavors will trigger the submission of a Phase II application that will advance the program from Early Lead Optimization through to Candidate Selection.

Public Health Relevance

Novel therapies with potent and selective activity against BK polyomavirus (BKPyV) are urgently needed to prevent BK-induced nephropathy (BKVN), ureteral stenosis and hemorrhagic cystitis in immunosuppressed individuals following transplantation. We propose to execute an innovative high throughput screening campaign. This screen is expected to yield novel compounds targeting BKPyV replication that will serve as starting points for medicinal chemistry hit-to-lead efforts. If successful, we will deliver one or more new lead series targeting BKPyV infection.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Small Business Innovation Research Grants (SBIR) - Phase I (R43)
Project #
1R43AI124925-01A1
Application #
9200219
Study Section
Special Emphasis Panel (ZRG1-IDM-X (10)B)
Program Officer
Dempsey, Walla L
Project Start
2016-07-02
Project End
2018-06-30
Budget Start
2016-07-02
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$341,629
Indirect Cost
Name
Venatorx Pharmaceuticals, Inc.
Department
Type
DUNS #
962754037
City
Malvern
State
PA
Country
United States
Zip Code
19355