The goal of the current project is to revise a prototype of a computerized attention training program (Memory Lane-Amplified Attention Training, M-AAT) designed for age-related cognitive decline completed in Phase I, and conduct a multi-site, randomized, controlled trial to establish efficacy in this population. As a group, individuals with age-related cognitive decline tend to have poorer long-term prognosis and are more likely to require managed care than individuals without similar declines. Our recent studies are among the first to demonstrate that M-AAT, targeting sustained attention and cognitive control, can produce lasting benefits. The overall goal of the current project is to measure 3 co-primary outcomes: attention, executive function and functional capacity. Evidence from our Phase I trial shows that M-AAT can improve attention and executive function. At the completion of this project we will have outcomes data sufficient for submission to the FDA for clearance as a medical device indicated for cognitive enhancement in age-related cognitive decline (ICD-9 Code R41.81).

Public Health Relevance

The goal of this project is to revise a prototype of a computerized cognitive training program (Memory Lane-Amplified Attention Training, M-AAT) for individual with age-related cognitive decline completed in Phase I, and conducts a multi-site, randomized controlled trial to demonstrate efficacy. This is important because this large population suffers from poor prognosis and a lack of viable treatment options.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44AG039965-03
Application #
8648497
Study Section
Special Emphasis Panel (ZRG1-RPHB-R (12))
Program Officer
Wagster, Molly V
Project Start
2014-06-15
Project End
2016-05-31
Budget Start
2014-06-15
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
$522,064
Indirect Cost
Name
Brain Plasticity, Inc.
Department
Type
DUNS #
831447730
City
San Francisco
State
CA
Country
United States
Zip Code
94105