Shock wave lithotripsy (SWL) is the first line treatment for the majority of patients with kidney stones. The gold standard in SWL is still considered to be the Dornier HM3, which was the first lithotripter introduced into the US. The HM3 is an electrohydraulic lithotripter (EHL) that uses a single underwater "sparker" as a shock wave source. The HM3 has the drawback that the electrodes erode quickly and must be replaced in the middle of a procedure, and causes significant side effects. This project is to develop optimized arrays several sparkers in small ellipsoidal reflectors that last for several procedures and break stones more effectively. The flexibility in placement of the sparkers allows space for an in-line probe to monitor stone location during treatment, which will result in fewer pressure pulses missing the stone and reduce damage to surrounding tissue. The specific project objectives are to optimize sparker arrays, including the use of double pulses by breaking both artificial and actual kidney stones, develop an in-line probe and conduct animal studies to investigate side-effects and to support an IDE. A successful Phase II will lead to the development of a prototype and clinical studies and subsequent commercialization.

Public Health Relevance

This research can lead to improved treatment of kidney stones. A successful new lithotripter will have a higher percentage of successes (reducing the number of repeat procedures), less side effects to the patient and will operate for several procedures without having to replace the sparker (which currently is replaced during each procedure).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Business Innovation Research Grants (SBIR) - Phase II (R44)
Project #
2R44DK089703-02A1
Application #
8310488
Study Section
Special Emphasis Panel (ZRG1-DKUS-G (12))
Program Officer
Kirkali, Ziya
Project Start
2010-09-01
Project End
2014-06-30
Budget Start
2012-09-17
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$469,999
Indirect Cost
Name
Phoenix Science and Technology, Inc.
Department
Type
DUNS #
927281949
City
Chelmsford
State
MA
Country
United States
Zip Code
01824