Essential Tremor (ET) is the single most common motion disorder, affecting 10 million people in the US alone. Due to the debilitating muscle movements associated with this disease, people with ET have difficulty in performing daily functions such as eating and drinking. As a result, many people become socially isolated and are also forced to retire from occupations held before the disease onset. Unfortunately, current pharmacological treatments have limited effectiveness in abating tremor, and surgical procedures can be expensive and invasive. To solve this problem, Lynx Design is investigating a cost-effective, lightweight, hand- held stabilization device called the ACT (Active Cancellation of Tremor) system. During Phase I work, a state- of-the-art hand-held prototype was developed and tested, demonstrating a reduction of tremor disturbances by up to 80% (for 1-2 cm). This result exceeded Phase I goals for technical feasibility and showed promise for future applications. Proposed Phase II work will focus on developing the ACT system further through a combination of clinical research and R&D. Key developments will focus on: 1) demonstrating/characterizing the technology's efficacy 2) improving control and long-term reliability and 3) designing the system for general use in daily activities (based on patient feedback). Detailed plans to commercialize the ACT system in the growing assistive device market are in place and will be executed after the Phase II work. The resulting distribution of the ACT technology will impact the growing population of ET sufferers, positively impacting their quality of life.
Lynx Design proposes to develop and commercialize an active tremor cancellation technology that will assist individuals affected by motion disorders such as Essential Tremor. Preliminary studies have demonstrated both feasibility of the technology and a strong unmet demand among suffering patients. The proposed system will be used to facilitate daily living, reduce social isolation, and re-enable the affected public to participate in activities and occupations that were lost upon disease onset.
|Soileau, Michael J; Persad, Carol; Taylor, Jennifer et al. (2014) Caregiver burden in patients with Parkinson disease undergoing deep brain stimulation: an exploratory analysis. J Parkinsons Dis 4:517-21|
|Pathak, Anupam; Redmond, John A; Allen, Michael et al. (2014) A noninvasive handheld assistive device to accommodate essential tremor: a pilot study. Mov Disord 29:838-42|
|Chou, Kelvin L; Lenhart, Adrienne; Koeppe, Robert A et al. (2014) Abnormal MoCA and normal range MMSE scores in Parkinson disease without dementia: cognitive and neurochemical correlates. Parkinsonism Relat Disord 20:1076-80|
|Weathers, Shiao-Pei S; Kotagal, Vikas; Bohnen, Nicolaas I et al. (2014) Risky driving and pedunculopontine nucleus-thalamic cholinergic denervation in Parkinson disease. Parkinsonism Relat Disord 20:13-6|
|Chou, Kelvin L; Taylor, Jennifer L; Patil, Parag G (2013) The MDS-UPDRS tracks motor and non-motor improvement due to subthalamic nucleus deep brain stimulation in Parkinson disease. Parkinsonism Relat Disord 19:966-9|