Abstract

This is a Shannon Award providing partial support for research projects that fall short of the assigned institute's funding range but are in the margin of excellence. The Shannon award is intended to provide support to test the feasibility of the approach; develop further tests and refine research techniques; perform secondary analysis of available data sets; or conduct discrete projects that can demonstrate the PI's research capabilities or lend additional weight to an already meritorious application. Further scientific data for the CRISP System are unavailable at this time.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
James A. Shannon Director's Award (R55)
Project #
1R55DK044632-01A1
Application #
3509712
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1992-09-30
Project End
1993-04-30
Budget Start
1992-09-30
Budget End
1993-04-30
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Tai, Kenneth P; Kamdar, Karishma; Yamaki, Jason et al. (2015) Microbicidal effects of ?- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun 21:17-29
Tai, Kenneth P; Le, Valerie V; Selsted, Michael E et al. (2014) Hydrophobic determinants of ?-defensin bactericidal activity. Infect Immun 82:2195-202
Patil, Amar A; Ouellette, Andre J; Lu, Wuyuan et al. (2013) Rattusin, an intestinal ?-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother 57:1823-31
Schaal, Justin B; Tran, Dat; Tran, Patti et al. (2012) Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One 7:e51337
Tongaonkar, Prasad; Golji, Amir E; Tran, Patti et al. (2012) High fidelity processing and activation of the human ?-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One 7:e32469
Mastroianni, Jennifer R; Costales, Jessica K; Zaksheske, Jennifer et al. (2012) Alternative luminal activation mechanisms for paneth cell ?-defensins. J Biol Chem 287:11205-12
Burkhardt, Amanda M; Tai, Kenneth P; Flores-Guiterrez, Juan P et al. (2012) CXCL17 is a mucosal chemokine elevated in idiopathic pulmonary fibrosis that exhibits broad antimicrobial activity. J Immunol 188:6399-406
Garcia, Angie E; Tai, Kenneth P; Puttamadappa, Shadakshara S et al. (2011) Biosynthesis and antimicrobial evaluation of backbone-cyclized ?-defensins. Biochemistry 50:10508-19
Shanahan, Michael T; Tanabe, Hiroki; Ouellette, Andre J (2011) Strain-specific polymorphisms in Paneth cell ýý-defensins of C57BL/6 mice and evidence of vestigial myeloid ýý-defensin pseudogenes. Infect Immun 79:459-73
Ouellette, Andre Joseph (2011) Paneth cell ýý-defensins in enteric innate immunity. Cell Mol Life Sci 68:2215-29

Showing the most recent 10 out of 17 publications