Brown, Solange P., Johns Hopkins University The broad goal of this proposal is to understand the types of cortical information that are integrated within the claustrum, a poorly understood brain structure that forms extensive reciprocal connections with the cortex. Studies have correlated abnormalities in the size and the activity of the claustrum with neuropsychiatric symptoms in diseases like Alzheimer's disease and schizophrenia, but the function of the claustrum remains unclear. A number of theories have been proposed regarding the claustrum's role in sensory processing and cognition, but the paucity of information on its cellular and functional organization has made it difficult to validate any of these theories. The proposed study will elucidate the cellular and functional organization of the claustrum to test three major current hypotheses: 1) that the claustrum plays a role in multimodal sensory integration, 2) that the claustrum plays a role in the bilateral coordination of sensorimotor behaviors involved in the exploration of the environment, and 3) that the claustrum plays a role in top-down control of the cortical response to sensory input. To test these hypotheses, we will use an innovative combination of approaches including rabies-based trans-synaptic tracing approaches, unitary recordings of synaptic connections among retrogradely and genetically labeled neurons, optogenetic circuit-mapping techniques, and in vivo studies. By assessing these theories of claustral function, we will determine mechanisms by which the claustrum influences cortical activity in the healthy brain and provide important insights into its contributions to abnormalities in sensory processing and cognition in neurologic and psychiatric diseases.

Public Health Relevance

Brown, Solange P., Johns Hopkins University Abnormalities in the structure and activity of the claustrum have been identified in neurologic and psychiatric diseases including Alzheimer's disease and schizophrenia. However, little is understood about the function of the claustrum, which forms widespread reciprocal connections with the neocortex. These experiments will test the current major theories of claustral function, a first step in developing better diagnostic tools and treatments for neurologic and psychiatric diseases that lead to alterations in sensory processing and cognition.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
High Priority, Short Term Project Award (R56)
Project #
1R56NS085121-01A1
Application #
9293861
Study Section
Mechanisms of Sensory, Perceptual, and Cognitive Processes Study Section (SPC)
Program Officer
Gnadt, James W
Project Start
2016-08-01
Project End
2017-07-31
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Baker, Arielle; Kalmbach, Brian; Morishima, Mieko et al. (2018) Specialized Subpopulations of Deep-Layer Pyramidal Neurons in the Neocortex: Bridging Cellular Properties to Functional Consequences. J Neurosci 38:5441-5455
Liu, Hongcheng; Du, Guangwei; Zhang, Lijun et al. (2016) Folded concave penalized learning in identifying multimodal MRI marker for Parkinson's disease. J Neurosci Methods 268:1-6