The broad goals of the MBRS/SCORE program at UPRM (University of Puerto Rico, Mayaguez) are, first to increase the competitiveness of UPRM-MBRS researchers and, second to increase the competitiveness of UPRM science and engineering departments through greater participation in MBRS/SCORE. As 98% enrollment and 90% of the faculty are minority U.S. citizens, these goals are consistent with the MBRS objective of increasing the number of underrepresented minorities conducting biomedical research through support of scientifically meritorious and biomedically relevant research by faculty members at minority-serving institutions. These goals are also consistent with the published UPRM objectives for faculty development and support of competitive research. The specific goals are to: (1) increase the number of new projects submitted as a part of the institutional proposal;(2) increase the number of peer-reviewed publications by MBRS researchers;(3) increase the number of MBRS-related presentations at national (U.S.) research meetings;and (4) promote transition of MBRS/SCORE researchers to mainstream funding from NIH or other agencies. Significant progress has been made in all the objectives in the last funding cycle. Six participating departments, Biology, Chemistry, Marine Sciences, Chemical Engineering, Mechanical Engineering and Electrical Engineering with a total of 13 subprojects have been submitted with this proposal. Thirteen faculty members from these departments are participating as principal investigators or co-investigators with a minimum of 25% effort. Areas of research include disease processes, biophysical chemistry, molecular biology, biochemistry, methods of drug administration and nanoscaffolds in osseointegration. The successful undertaking of these projects and the completion of the program goals will further increase the competitiveness of our departments and researchers.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Minority Biomedical Research Support - MBRS (S06)
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Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Zlotnik, Hinda
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University of Puerto Rico Mayaguez
Schools of Arts and Sciences
United States
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Díaz Casas, Adalberto; Chazin, Walter J; Pastrana-Ríos, Belinda (2017) Prp40 Homolog A Is a Novel Centrin Target. Biophys J 112:2529-2539
Lara Rodriguez, L; Sundaram, P A (2016) Corrosion behavior of plasma electrolytically oxidized gamma titanium aluminide alloy in simulated body fluid. Mater Chem Phys 181:67-77
Bueno-Vera, J A; Torres-Zapata, I; Sundaram, P A et al. (2015) Electrochemical characterization of MC3T3-E1 cells cultured on ?TiAl and Ti-6Al-4V alloys. Bioelectrochemistry 106:316-27
Pastrana-Rios, Belinda; Del Valle Sosa, Liliana; Santiago, Jorge (2015) Trifluoroacetic acid as excipient destabilizes melittin causing the selective aggregation of melittin within the centrin-melittin-trifluoroacetic acid complex. Struct Dyn 2:041711
Santiago-Medina, P; Sundaram, P A; Diffoot-Carlo, N (2015) Titanium Oxide: A Bioactive Factor in Osteoblast Differentiation. Int J Dent 2015:357653
Santiago-Medina, Pricilla; Sundaram, Paul A; Diffoot-Carlo, Nanette (2014) The effects of micro arc oxidation of gamma titanium aluminide surfaces on osteoblast adhesion and differentiation. J Mater Sci Mater Med 25:1577-87
Vera, José L; Rullán, Jorge; Santos, Natasha et al. (2014) Functionalized ferrocenes: The role of the para substituent on the phenoxy pendant group. J Organomet Chem 749:204-214
Lara Rodriguez, L; Sundaram, P A; Rosim-Fachini, E et al. (2014) Plasma electrolytic oxidation coatings on ?TiAl alloy for potential biomedical applications. J Biomed Mater Res B Appl Biomater 102:988-1001
Dominguez-Garcia, Moralba; Ortega-Zuniga, Carlos; Melendez, Enrique (2013) New tungstenocenes containing 3-hydroxy-4-pyrone ligands: antiproliferative activity on HT-29 and MCF-7 cell lines and binding to human serum albumin studied by fluorescence spectroscopy and molecular modeling methods. J Biol Inorg Chem 18:195-209
Pastrana-Rios, Belinda; Reyes, Myrna; De Orbeta, Jessica et al. (2013) Relative stability of human centrins and its relationship to calcium binding. Biochemistry 52:1236-48

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