The NMR Facility at the Department of Chemistry and Biochemistry UC Santa Barbara houses two outdated NMR spectrometers dedicated to chemistry research of organic/inorganic small molecules, peptides and polymers. Funding is requested to replace the console for a 16-year old 500 MHz spectrometer with a state-of-the-art digital console and a room-temperature universal probe optimized for both 1H and X-nucleus detection. Our current, older generation Varian Untity Inova console lacks basic automation features that are common in current generation of consoles used in routine NMR analysis, severely restricting instrument throughput and efficiency. Moreover, as the stability of the console components deteriorates, vendor support and availability of replacement parts are diminishing. The requested, state-of-the-art console and probe replacements offer much needed auto- tuning and shimming capabilities, complete digital control of signal and RF pulse routing, improved lock sensitivity and stability, reduced noise and artifacts, and expanded experimental capabilities. Moreover, the latest Bruker SmartProbe offers more than double the 1H sensitivity compared to what we currently have on the instrument while achieving a moderate sensitivity gain for all X-nuclei. The upgrade also delivers an expanded variable temperature range, improved temperature stability and more convenient low-temperature setup. The upgraded spectrometer will continue to play an essential role in meeting the research needs of various NIH-funded projects in the department.
NMR is the most important analytical technique for organic synthesis. The upgrade describe in this application will substantially enhance or in certain cases enable research of five NIH funded research groups whose focus is in the areas of the development of new organic synthesis methods for the discovery of therapeutic agents and the synthesis of novel drug leads based on bioactive molecules from nature.
|Handa, Sachin; Andersson, Martin P; Gallou, Fabrice et al. (2016) HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature. Angew Chem Int Ed Engl 55:4914-8|
|Alvarado, Joseph; Fournier, Jeremy; Zakarian, Armen (2016) Synthesis of Functionalized Dihydrobenzofurans by Direct Aryl C-O Bond Formation under Mild Conditions. Angew Chem Int Ed Engl 55:11625-8|
|Hartmann, Nathaniel J; Wu, Guang; Hayton, Trevor W (2015) Synthesis of a ""Masked"" Terminal Nickel(II) Sulfide by Reductive Deprotection and its Reaction with Nitrous Oxide. Angew Chem Int Ed Engl 54:14956-9|
|Handa, Sachin; Slack, Eric D; Lipshutz, Bruce H (2015) Nanonickel-catalyzed Suzuki-Miyaura cross-couplings in water. Angew Chem Int Ed Engl 54:11994-8|
|Sandoval, David; Samoshin, Andrey V; Read de Alaniz, Javier (2015) Asymmetric Electrophilic Î±-Amination of Silyl Enol Ether Derivatives via the Nitrosocarbonyl Hetero-ene Reaction. Org Lett 17:4514-7|
|Isley, Nicholas A; Linstadt, Roscoe T H; Kelly, Sean M et al. (2015) Nucleophilic Aromatic Substitution Reactions in Water Enabled by Micellar Catalysis. Org Lett 17:4734-7|
|Handa, Sachin; Wang, Ye; Gallou, Fabrice et al. (2015) Sustainable Fe-ppm Pd nanoparticle catalysis of Suzuki-Miyaura cross-couplings in water. Science 349:1087-91|
|Fisher, David J; Burnett, G Leslie; Velasco, RocÃo et al. (2015) Synthesis of Hindered Î±-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds. J Am Chem Soc 137:11614-7|
|Ji, Kegong; D'Souza, Brendan; Nelson, Jon et al. (2014) Gold-Catalyzed Oxidation of Propargylic Ethers with Internal C-C Triple Bonds: Impressive Regioselectivity Enabled by Inductive Effect. J Organomet Chem 770:142-145|
|Lu, Ping; Mailyan, Artur; Gu, Zhenhua et al. (2014) Enantioselective synthesis of (-)-maoecrystal V by enantiodetermining C-H functionalization. J Am Chem Soc 136:17738-49|