Funds are requested to acquire a cryogenic probe for a 600 MHz NMR spectrometer to support chemical biology and biomedical research efforts across New York University (NYU), including the Department of Chemistry and the School of Medicine. The equipment will be housed in the Shared Instrumentation Facility for Life Science in the Department of Chemistry. This facility was built with support from the NIH/NCRR in the form of a Research Facilities Improvement Grant. The proposed cryogenic probe will support nine NIH funded users and will provide technology currently not available at NYU (i.e., no cryoprobe on campus). The cryogenic probe will include highly sensitive 1H and 13C detection (increase of 3-4-fold) with the ability to perform all triple resonance experiments needed to characterize the structural dynamics of biomacromolecules using state-of- the-art solution NMR methodology. This equipment will also allow researchers limited in sample mass to carry out sensitive structural studies. NYU has a partial membership at the New York Structural Biology Center that is insufficient to meet the NMR needs of the NIH-funded researchers at NYU. Therefore, having a cryogenic probe on campus will facilitate increased access to this technology that will be essential to revealing molecular interactions important in human health and disease.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10OD016343-01A1
Application #
8639823
Study Section
Special Emphasis Panel (ZRG1-BCMB-S (30))
Program Officer
Levy, Abraham
Project Start
2014-06-01
Project End
2015-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
1
Fiscal Year
2014
Total Cost
$359,704
Indirect Cost
Name
New York University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012