Abstract

Funding is requested for a new electronics console and magnetic field gradient/shim coil system to replace existing equipment on a 4.7 Tesla 33 cm bore horizontal magnetic resonance imaging (MRI) magnet. Projects to be supported and vastly enhanced with this state of the art high performance instrumentation fall in the areas of neuroscience (functional brain imaging applications and development, brain pharmacology, cancer, neurovascular pathology, neurodegeneration), biomineralization (developmental biology of bone, bone mineral and matrix composition and crystal structure, noninvasive imaging/nondestructive evaluation of bone and engineered biomaterials), and vascular biology (multimodality/multispectral imaging of arterial walls and atherosclerotic plaque). The existing console and gradient system are no longer adequate for the needs of the supported projects, and are no longer supported by the manufacturer. The strikingly enhanced performance of the upgraded instrument will dramatically improve the quality of MR data obtained in these studies. Most importantly, new experimental opportunities for these projects will become possible that cannot be considered with only the existing instrumentation. The research projects to be supported by this new instrumentation are multidisciplinary, cutting across several departments and institutions, which include several hospitals and universities. The projects address a mix of basic scientific and public health issues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR016811-01
Application #
6440845
Study Section
Special Emphasis Panel (ZRG1-SRB (04))
Program Officer
Tingle, Marjorie
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
1
Fiscal Year
2002
Total Cost
$500,000
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Takahashi, Emi; Hayashi, Emiko; Schmahmann, Jeremy D et al. (2014) Development of cerebellar connectivity in human fetal brains revealed by high angular resolution diffusion tractography. Neuroimage 96:326-33
Xu, Gang; Takahashi, Emi; Folkerth, Rebecca D et al. (2014) Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights. Cereb Cortex 24:579-92
Edlow, Brian L; Haynes, Robin L; Takahashi, Emi et al. (2013) Disconnection of the ascending arousal system in traumatic coma. J Neuropathol Exp Neurol 72:505-23
White, Nathan S; Leergaard, Trygve B; D'Arceuil, Helen et al. (2013) Probing tissue microstructure with restriction spectrum imaging: Histological and theoretical validation. Hum Brain Mapp 34:327-46
Takahashi, Emi; Song, Jae W; Folkerth, Rebecca D et al. (2013) Detection of postmortem human cerebellar cortex and white matter pathways using high angular resolution diffusion tractography: a feasibility study. Neuroimage 68:105-11
Edlow, Brian L; Takahashi, Emi; Wu, Ona et al. (2012) Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders. J Neuropathol Exp Neurol 71:531-46
Mintzopoulos, Dionyssios; Ackerman, Jerome L; Song, Yi-Qiao (2011) MRI of trabecular bone using a decay due to diffusion in the internal field contrast imaging sequence. J Magn Reson Imaging 34:361-71
Klein, Johannes C; Rushworth, Matthew F S; Behrens, Timothy E J et al. (2010) Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography. Neuroimage 51:555-64
Cao, Haihui; Ackerman, Jerome L; Hrovat, Mirko I et al. (2008) Quantitative bone matrix density measurement by water- and fat-suppressed proton projection MRI (WASPI) with polymer calibration phantoms. Magn Reson Med 60:1433-43
D'Arceuil, Helen; Liu, Christina; Levitt, Pat et al. (2008) Three-dimensional high-resolution diffusion tensor imaging and tractography of the developing rabbit brain. Dev Neurosci 30:262-75

Showing the most recent 10 out of 16 publications