The progress of many aspects of biomedical research is critically dependent on the development of new synthetic compounds and biomaterials. A key tool for synthetic researchers is mass spectrometry and the aim of this request is to provide the necessary mass spectrometry instrumentation to enhance discovery of new compounds and biomaterials. A modern state-of-the-art time-of-flight (TOF) mass spectrometer with appropriate accessories for rapid analysis for a variety of new synthetic compounds is requested. This system will be equipped with a combination electrospray (ESI) and atmospheric pressure chemical ionization (APCI) source, an inlet for introduction of internal standard for exact mass measurements, a rapid HPLC system for chemical separations when needed, a computer-controlled switching valve for direct loop injection when appropriate, an autosampler, and open access software. This instrument will be a vital component to support the specific aims of over 8 NIH-funded projects that enhance the understanding of the synthetic process, create new materials and devices for biomedical research, and develop diagnostic and therapeutic agents. The proposed time-of-flight mass spectrometer system will be supported and administered by the UCLA Molecular Instrumentation Center (MIC), a campus-wide, integrated facility formed to enhance the accessibility of existing shared, sophisticated instrumentation facilities to the broader research community at the institution. The availability of a mass spectrometer in a campus core facility will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease.
A mass spectrometer is requested for a campus-wide core facility, which will greatly facilitate the progress of a wide range of projects designed to create new molecules that will produce therapeutics and diagnostic methods for a number of human diseases. The research will impact a range of human health issues, including various bacterial and viral diseases, tuberculosis, breast cancer, hormone refractory prostate cancer, heart disease, diabetes and Alzheimer's disease.
| Boit, Timothy B; Weires, Nicholas A; Kim, Junyong et al. (2018) Nickel-Catalyzed Suzuki-Miyaura Coupling of Aliphatic Amides. ACS Catal 8:1003-1008 |
| Barber, Joyann S; Yamano, Michael M; Ramirez, Melissa et al. (2018) Diels-Alder cycloadditions of strained azacyclic allenes. Nat Chem 10:953-960 |
| Picazo, Elias; Anthony, Sarah M; Giroud, Maude et al. (2018) Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers. J Am Chem Soc 140:7605-7610 |
| Picazo, Elias; Morrill, Lucas A; Susick, Robert B et al. (2018) Enantioselective Total Syntheses of Methanoquinolizidine-Containing Akuammiline Alkaloids and Related Studies. J Am Chem Soc 140:6483-6492 |
| Li, Li; Tang, Man-Cheng; Tang, Shoubin et al. (2018) Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. J Am Chem Soc 140:2067-2071 |
| Weires, Nicholas A; Caspi, Daniel D; Garg, Neil K (2017) Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides. ACS Catal 7:4381-4385 |
| Sato, Michio; Dander, Jacob E; Sato, Chizuru et al. (2017) Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases. J Am Chem Soc 139:5317-5320 |
| Simmons, Bryan J; Hoffmann, Marie; Hwang, Jaeyeon et al. (2017) Nickel-Catalyzed Reduction of Secondary and Tertiary Amides. Org Lett 19:1910-1913 |
| Medina, Jose M; Ko, Jeong Hoon; Maynard, Heather D et al. (2017) Expanding the ROMP Toolbox: Synthesis of Air-Stable Benzonorbornadiene Polymers by Aryne Chemistry. Macromolecules 50:580-586 |
| Dander, Jacob E; Baker, Emma L; Garg, Neil K (2017) Nickel-catalyzed transamidation of aliphatic amide derivatives. Chem Sci 8:6433-6438 |
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