A multiphoton laser scanning microscope is requested for the use of eight major users at the Mount Sinai School of Medicine. The instrument will be used for multichannel fluorescence and second harmonic generation imaging of a variety of organs and tissue preparations including both ex-vivo and in-vivo observations. The investigators, from the Departments of Gene and Cell Medicine, Immunobiology, Medicine, Neurology, Neurosurgery and Orthopedic Surgery, will study atherosclerotic plaques, HIV-associated nephropathy, tumor metastasis, tendon damage and repair, subarachnoid hemorrhage, vestibular sensory organs, immune system dynamics, and renal epithelial cell function. The instrument will be situated in and managed by the Microscopy Shared Resource Facility, an ongoing and successful institution-wide core which houses other confocal and widefield microscopes and is currently used by personnel from more than 100 Mount Sinai laboratories, The facility's staff of two full time biomedical engineers will provide supervision and training for users of the requested instrument and will be responsible for its maintenance.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biomedical Research Support Shared Instrumentation Grants (S10)
Project #
1S10RR026639-01
Application #
7792822
Study Section
Special Emphasis Panel (ZRG1-CB-J (31))
Program Officer
Levy, Abraham
Project Start
2010-05-27
Project End
2011-05-26
Budget Start
2010-05-27
Budget End
2011-05-26
Support Year
1
Fiscal Year
2010
Total Cost
$500,000
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Neurosciences
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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