This application is a competing renewal for an Institutional Ruth L. Kirschstein NRSA on the """"""""Genetic Aspects of Alcoholism."""""""" The objective of this training program is to provide high level predoctoral and postdoctoral research training on various aspects of the genetics of alcoholism, and mechanisms underlying high alcohol drinking behavior. The main focus of the research training is on the genetic, biological and molecular basis of high alcohol -drinking and -seeking behaviors. Major topics of research include neuronal mechanisms underlying high alcohol-drinking and -seeking behavior;the genetics of alcohol preference in selectively bred rodent lines;studies of factors that regulate the expression of genes relevant to alcoholism;analysis of the extent that genetically-influenced biobehavioral factors such as disinhibition-impulsivity and tolerance contribute to alcoholism risks in human populations;effects of genetics and alcohol drinking on protein and gene expression in selectively bred rodent lines;neuropsycho-pharmacological and neuroimaging studies on alcohol craving in humans and rodents;co-morbidity of alcohol addiction and schizophrenia in rodent models;mechanisms and genetics underlying co-abuse of alcohol and nicotine;and neurodevelopmental abnormalities of fetal alcohol syndrome in rodent models. The rationale for the research training program is that we do not yet fully understand how genetics influence alcohol drinking behavior. This is a very important topic and the field needs highly trained research investigators proficient in the newest genetic, molecular and behavioral neuroscience approaches. In addition, our program offers translational research training, encompassing both human and animal studies. The program is designed to give the trainee exposure to and participation in high- powered research projects in which state-of-the-art methodologies are used. We expect to support 7 predoctoral trainees (after their first 2 years of graduate study), and 3 postdoctoral trainees (usually with 0-1 year of post-graduate experience). We anticipate supporting trainees for at least 3 years (some predoctoral trainees may take 1 or 2 additional years).
There is convincing evidence that alcoholism runs in families. Identifying the genes and neurobiological systems that contribute to alcohol use and abuse would greatly contribute toward understanding and treating alcohol use disorders.
|Deehan Jr, Gerald A; Knight, Christopher P; Waeiss, R Aaron et al. (2016) Peripheral Administration of Ethanol Results in a Correlated Increase in Dopamine and Serotonin Within the Posterior Ventral Tegmental Area. Alcohol Alcohol 51:535-40|
|Kasten, Chelsea R; Boehm 2nd, Stephen L (2016) Preclinical Medication Development: New Targets and New Drugs. Alcohol Clin Exp Res 40:1418-24|
|Kasten, C R; Frazee, A M; Boehm 2nd, S L (2016) Developing a model of limited-access nicotine consumption in C57Bl/6J mice. Pharmacol Biochem Behav 148:28-37|
|Hauser, Sheketha R; Deehan Jr, Gerald A; Knight, Christopher P et al. (2016) Parameters of Context-Induced Ethanol (EtOH)-Seeking in Alcohol-Preferring (P) Rats: Temporal Analysis, Effects of Repeated Deprivation, and EtOH Priming Injections. Alcohol Clin Exp Res 40:2229-2239|
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|Beckwith, Steven Wesley; Czachowski, Cristine Lynn (2016) Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding andÂ Self-Administration of Alcohol. Alcohol Clin Exp Res 40:1100-10|
|Fritz, Brandon M; Quoilin, Caroline; Kasten, Chelsea R et al. (2016) Concomitant Caffeine Increases Binge Consumption of Ethanol in Adolescent and Adult Mice, But Produces Additive Motor Stimulation Only in Adolescent Animals. Alcohol Clin Exp Res 40:1351-60|
|Knight, Christopher P; Hauser, Sheketha R; Deehan Jr, Gerald A et al. (2016) Oral Conditioned Cues Can Enhance or Inhibit Ethanol (EtOH)-Seeking and EtOH-Relapse Drinking by Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 40:906-15|
|Oberlin, Brandon G; Dzemidzic, Mario; Harezlak, Jaroslaw et al. (2016) Corticostriatal and Dopaminergic Response to Beer Flavor with Both fMRI and [(11) C]raclopride Positron Emission Tomography. Alcohol Clin Exp Res 40:1865-73|
|Hershberger, Alexandra R; VanderVeen, J Davis; Karyadi, Kenny A et al. (2016) Transitioning From Cigarettes to Electronic Cigarettes Increases Alcohol Consumption. Subst Use Misuse 51:1838-45|
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