This program for pre- and post-doctoral training supports the training of specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol use disorders. Twenty-three members of the graduate faculty of the Oregon Health &Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU-Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of common interest: (1) genetic bases for alcohol and responses and risk, (2) learned and unlearned determinants of alcohol and drug reward, (3) neurobiological bases for the rewarding and aversive effects of alcohol and other drugs, (4) neuroadaptive mechanisms associated with ethanol dependence and sensitization, and (5) effects of alcohol on memory and cognition. Technical strategies reflect four levels of analysis: I. Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological, III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level. Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in alcohol and other abused drugs, and extensive and continuous participation in research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors'resources. Three postdoctoral trainees per year with 0-1 years of postdoctoral experience will be supported by the training grant for 2 years. We have a well developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.
Alcoholism is a chronic, relapsing disease that directly affects over 15 million people just in the United States. The cost to society and individuals related to persons suffering from alcoholism is extreme. This training program will create experts capable of carrying on meaningful research on the biological mechanisms underlying the etiology, treatment and prevention of alcoholism.
|Crabbe, J C; Metten, P; Belknap, J K et al. (2014) Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice. Genes Brain Behav 13:236-46|
|Fritz, Brandon M; Cordero, Kristy A; Barkley-Levenson, Amanda M et al. (2014) Genetic relationship between predisposition for binge alcohol consumption and blunted sensitivity to adverse effects of alcohol in mice. Alcohol Clin Exp Res 38:1284-92|
|Young, Emily A; Dreumont, Sarah E; Cunningham, Christopher L (2014) Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior. Neurobiol Learn Mem 108:28-37|
|Barkley-Levenson, Amanda M; Crabbe, John C (2014) High drinking in the dark mice: a genetic model of drinking to intoxication. Alcohol 48:217-23|
|McClendon, Evelyn; Chen, Kevin; Gong, Xi et al. (2014) Prenatal cerebral ischemia triggers dysmaturation of caudate projection neurons. Ann Neurol 75:508-24|
|Snelling, Christopher; Tanchuck-Nipper, Michelle A; Ford, Matthew M et al. (2014) Quantification of ten neuroactive steroids in plasma in Withdrawal Seizure-Prone and -Resistant mice during chronic ethanol withdrawal. Psychopharmacology (Berl) 231:3401-14|
|Tipps, Megan E; Moschak, Travis M; Mitchell, Suzanne H (2014) Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol. Drug Alcohol Depend 136:149-52|
|Gomez, Juan L; Ryabinin, Andrey E (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res 38:2436-44|
|Cozzoli, Debra K; Courson, Justin; Wroten, Melissa G et al. (2014) Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala. Neuropsychopharmacology 39:435-44|
|Pina, Melanie M; Cunningham, Christopher L (2014) Effects of dopamine receptor antagonists on the acquisition of ethanol-induced conditioned place preference in mice. Psychopharmacology (Berl) 231:459-68|
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