The Center for Alcohol Studies (CAS) training program at the University of North Carolina at Chapel Hill is designed to promote the development of promising pre- and post-doctoral research fellows as independent investigators and future University faculty members who will investigate the pathogenesis of alcoholism and alcohol abuse using modern molecular medicine techniques. Training of the postdoctoral fellows will be individualized with the most important component being the research conducted by the trainee in the faculty mentor's laboratory. Particular emphasis will be on modern molecular biological and biochemical techniques. Additional training will include didactic courses, seminars and conferences, and activities on responsible conduct of research. The training faculty will consist of 13 funded investigators from 10 basic science and clinical departments and centers at the University of North Carolina at Chapel Hill. The faculty has a documented history of close interactions. The trainees will benefit from the unique strengths of alcohol research at the University of North Carolina, which include the CAS, center for Gastrointestinal Biology and Diseases (CGIBD), with its research cores, UNC-Neuroscience Center, a research-oriented Mental Health Research Center with its research cores in Psychiatry, a Gene Therapy Center and the Program in Molecular Biology and Biotechnology. The training program will be directed by Dr. Fulton T. Crews with the assistance of three senior alcohol researchers, Drs. David Brenner, George Breese and Leslie Morrow, who will constitute the Training Program Advisory Committee. The program proposes to recruit three post-doctoral fellows and one pre-doctoral fellow. The trainees will receive two and usually more years of research training with external support sought for later years. This institutional training grant will promote intensive training in molecular techniques and basic pathophysiology in a stimulating environment leading to broadly trained independent investigators capable of adapting to the rapid advances in research in the 21st century.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AA007573-15
Application #
8249768
Study Section
Special Emphasis Panel (ZAA1-HH (10))
Program Officer
Grandison, Lindsey
Project Start
1997-04-01
Project End
2013-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
15
Fiscal Year
2012
Total Cost
$269,271
Indirect Cost
$18,883
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Elton, Amanda; Smith, Christopher T; Parrish, Michael H et al. (2016) Neural Systems Underlying Individual Differences in Intertemporal Decision-making. J Cogn Neurosci :1-13
Randall, Patrick A; Cannady, Reginald; Besheer, Joyce (2016) The nicotine + alcohol interoceptive drug state: contribution of the components and effects of varenicline in rats. Psychopharmacology (Berl) 233:3061-74
Crews, Fulton T; Vetreno, Ryan P (2016) Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacology (Berl) 233:1543-57
Crews, Fulton T; Vetreno, Ryan P; Broadwater, Margaret A et al. (2016) Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. Pharmacol Rev 68:1074-1109
Knapp, Darin J; Harper, Kathryn M; Whitman, Buddy A et al. (2016) Stress and Withdrawal from Chronic Ethanol Induce Selective Changes in Neuroimmune mRNAs in Differing Brain Sites. Brain Sci 6:
Li, Chia; Sugam, Jonathan A; Lowery-Gionta, Emily G et al. (2016) Mu Opioid Receptor Modulation of Dopamine Neurons in the Periaqueductal Gray/Dorsal Raphe: A Role in Regulation of Pain. Neuropsychopharmacology 41:2122-32
Carlson, Stephen L; Bohnsack, John Peyton; Morrow, A Leslie (2016) Ethanol Regulation of Synaptic GABAA α4 Receptors Is Prevented by Protein Kinase A Activation. J Pharmacol Exp Ther 357:10-6
Carlson, Stephen L; Bohnsack, J Peyton; Patel, Vraj et al. (2016) Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons. J Pharmacol Exp Ther 356:148-56
Werner, David F; Porcu, Patrizia; Boyd, Kevin N et al. (2016) Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids. Mol Cell Neurosci 72:1-8
Vetreno, Ryan P; Yaxley, Richard; Paniagua, Beatriz et al. (2016) Adult rat cortical thickness changes across age and following adolescent intermittent ethanol treatment. Addict Biol :

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