This competing continuation application requests support for 6 postdoctoral fellows for primary training in aspects of alcohol research related to 4 major tracks: (i) genetic epidemiology;(ii) gene discovery, (iii) developmental psychopathology and longitudinal studies, and (iv) cognitive neuroscience (principally involving electrophysiology studies). In addition to specialization in a primary discipline, trainees will be encouraged to obtain a sufficient familiarity with other focus areas to facilitate fruitful cross-disciplinary collaborations in their research careers. The training program will ordinarily be of 3 years duration, reflecting the diverse backgrounds of our applicant pool (e.g. clinical psychology, social work, psychiatry, mathematics, other behavioral science). The training program emphasizes a research apprenticeship model, combining research under the mentorship of one or more experienced research mentors with more formal training through didactic courses and seminar programs;
and aims to help trainees make progress on their pathway to independence through high-impact first author publications, refinement of research ideas that will support a first grant submission as PI, and assistance in collection of feasibility data to support a first submission. Six of 10 who have completed fellowships have successful NIH applications as PI;2 have applications in process;and 2 trained in an area (basic neuroscience) dropped in this competing application. Major strengths of the program are its affiliation with a flourishing Alcoholism Research Center, the availability of senior faculty with an extensive program of alcoholism research, representing expertise in many aspects of statistical, molecular and genetic epidemiologic research on alcoholism;the highly productive research environment;the availability of major genetic data-bases offering many opportunities for innovative analyses and high-impact publications;access to ongoing projects that offer many opportunities for trainees to obtain expertise in clinical research;the program's location in one of the nation's leading medical schools, allowing trainees to take advantage of a rich array of didactic courses and seminars and research experiences;and the long tradition of successful mentoring and research training of scientists and clinician scientists from diverse intellectual backgrounds.

Public Health Relevance

Parent-to-child transmission of alcoholism often is characterized by genetic inheritance occurring in the context of high-risk environmental exposures associated with parental alcoholism. Trainees will learn to study this process through genetic including gene discovery-, longitudinal, and cognitive neuroscience approaches.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1-HH (32))
Program Officer
Parsian, Abbas
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Washington University
Schools of Medicine
Saint Louis
United States
Zip Code
Munn-Chernoff, Melissa A; Grant, Julia D; Agrawal, Arpana et al. (2015) Are there common familial influences for major depressive disorder and an overeating-binge eating dimension in both European American and African American female twins? Int J Eat Disord 48:375-82
van den Berg, St├ęphanie M; de Moor, Marleen H M; McGue, Matt et al. (2014) Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet 44:295-313
Power, R A; Verweij, K J H; Zuhair, M et al. (2014) Genetic predisposition to schizophrenia associated with increased use of cannabis. Mol Psychiatry 19:1201-4
Koren, Rachel; Munn-Chernoff, Melissa A; Duncan, Alexis E et al. (2014) Is the relationship between binge eating episodes and personality attributable to genetic factors? Twin Res Hum Genet 17:65-71
Maciejewski, Dominique F; Creemers, Hanneke E; Lynskey, Michael T et al. (2014) Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? JAMA Psychiatry 71:699-705
Duncan, Alexis E; Munn-Chernoff, Melissa A; Hudson, Darrell L et al. (2014) Genetic and environmental risk for major depression in African-American and European-American women. Twin Res Hum Genet 17:244-53
Koren, Rachel; Duncan, Alexis E; Munn-Chernoff, Melissa A et al. (2014) Preliminary evidence for the role of HTR2A variants in binge eating in young women. Psychiatr Genet 24:28-33
Rogers, C E; Kidokoro, H; Wallendorf, M et al. (2013) Identifying mothers of very preterm infants at-risk for postpartum depression and anxiety before discharge. J Perinatol 33:171-6
Munn-Chernoff, Melissa A; von Ranson, Kristin M; Culbert, Kristen M et al. (2013) An examination of the representativeness assumption for twin studies of eating pathology and internalizing symptoms. Behav Genet 43:427-35
Munn-Chernoff, Melissa A; Duncan, Alexis E; Grant, Julia D et al. (2013) A twin study of alcohol dependence, binge eating, and compensatory behaviors. J Stud Alcohol Drugs 74:664-73

Showing the most recent 10 out of 36 publications