This is a renewal application for a pre- and post-doctoral Training Program in the Neuroimmunoendocrine Effects of Alcohol at Loyola University Stritch School of Medicine that is currently in Year 9. The training program faculty consists of a multidisciplinary group of well-funded basic scientists and clinicians with active research programs examining the neurobiological, immune and endocrine responses to alcohol exposure. The Training Faculty, i.e., those who can serve as primary mentors for T32-funded trainees, hold primary and secondary appointments in basic science and clinical departments and research institutes. This gives trainees a wide range of research areas from which to choose. Elizabeth J. Kovacs, PhD, Professor and Vice Chair in the Department of Surgery will continue to serve as the Director and PI of the Training Grant. She is a cellular immunologist with an international reputation for her work on endocrine effects on immunity after alcohol exposure. She will be assisted by Associate Director, Mary Druse-Manteuffel, PhD, Professor of Cell and Molecular Physiology, who works on neuronal consequences of fetal alcohol syndrome. They will lead the T32's Executive Committee, consisting of a subset of the Alcohol Research Program's faculty. Together, the members of the Executive Committee will oversee the recruitment of new trainees to the training program and monitor the progress of the fellows. Additionally, there is an External Advisory Committee, composed of four senior faculty who have extensive experience in alcohol research and/or in the training of graduate students and post-doctoral fellows. They will critically evaluate the training program and the research of the trainees. For this renewal application, the pool of pre-doctoral trainees will be expanded to include students in Loyola's new Integrated Program in Biomedical Sciences as well as students in traditional graduate programs: Cell Biology, Biochemistry, Neuroscience, Immunology, Physiology, and Pharmacology. With a significant contribution of graduate stipend support from the Dean's office, it is anticipated that the majority of the coursework will be completed prior to appointment to this training grant. This will allow T32-funded pre- doctoral trainees, like their post-doctoral counterparts, to spend a majority of their time doing research in the laboratory of one of the members of the Training Faculty. All trainees will take a Bioethics course, demonstrate proficiency in biostatistics and will hone their skills in writing and oral presentatio. Along with the Training Faculty, all trainees will attend Alcohol Research Program meetings. In an effort to expand the number of young people interested in alcohol research this renewal application will add short-term summer internships for medical students, undergraduates and high school students. These internships will be directed to trainees from under-represented minority backgrounds. The commitment of the Training Faculty to excellence in research and teaching will insure the successful preparation of trainees for careers as academic scientists in the field of alcohol research.

Public Health Relevance

Excessive alcohol consumption is the third leading lifestyle-related cause of death in the United States costing taxpayers $166 billion dollars annually. The deleterious effects of alcohol cross the age spectrum, from fetal alcohol exposure and adolescent binge drinking to multiple organ dysfunction in long-term chronic abusers. The interdisciplinary nature of the Training Faculty at Loyola University's Alcohol Research Program, with its diverse areas of research allowing trainees to study basic, clinical and translational projects, is an ideal environment for training the next generation of alcohol researchers.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZAA1)
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Jung, Kathy
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Loyola University Chicago
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Chen, Michael M; O'Halloran, Eileen B; Ippolito, Jill A et al. (2015) Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin. Shock 43:80-4
Przybycien-Szymanska, Magdalena M; Rao, Yathindar S; Prins, Sarah A et al. (2014) Parental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure. PLoS One 9:e89320
Chen, Michael M; Zahs, Anita; Chang, Sulie L et al. (2014) Street smarts of science for students. Nat Immunol 15:997-9
Plichta, Jennifer K; Droho, Steve; Curtis, Brenda J et al. (2014) Local burn injury impairs epithelial permeability and antimicrobial peptide barrier function in distal unburned skin. Crit Care Med 42:e420-31
Chen, Michael M; Zahs, Anita; Brown, Mary M et al. (2014) An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice. Am J Physiol Gastrointest Liver Physiol 307:G711-8
Prins, Sarah A; Przybycien-Szymanska, Magdalena M; Rao, Yathindar S et al. (2014) Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. PLoS One 9:e83166
Reder, Nicholas P; Davis, Christopher S; Kovacs, Elizabeth J et al. (2014) The diagnostic value of gastroesophageal reflux disease (GERD) symptoms and detection of pepsin and bile acids in bronchoalveolar lavage fluid and exhaled breath condensate for identifying lung transplantation patients with GERD-induced aspiration. Surg Endosc 28:1794-800
Fisichella, Piero Marco; Reder, Nicholas P; Gagermeier, James et al. (2014) Usefulness of pH monitoring in predicting the survival status of patients with scleroderma awaiting lung transplantation. J Surg Res 189:232-7
Moon, Kwan-Hoon; Tajuddin, Nuzhath; Brown 3rd, James et al. (2014) Phospholipase A2, oxidative stress, and neurodegeneration in binge ethanol-treated organotypic slice cultures of developing rat brain. Alcohol Clin Exp Res 38:161-9
Chen, Lin; Schrementi, Megan E; Ranzer, Matthew J et al. (2014) Blockade of mast cell activation reduces cutaneous scar formation. PLoS One 9:e85226

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