The primary objective of this proposal is to continue our aging-related research training efforts on both the University of Colorado Anschutz Medical Campus (UC-AMC) and the University of Colorado-Boulder Campus (UC-B). The focus of this second renewal of our 5-year training grant will be expanded to reflect the new title "Integrative Physiology of Aging". As with the past 2 funding cycles, the major participating programs will be the Division of Geriatric Medicine (DGM) and the Center for Human Nutrition (CHN) at UC-AMC, and the Department of Integrative Physiology (IPHY) at UC-B. However, the expanded focus will enable us to involve additional outstanding aging-related investigators from our 2 campuses as additional mentors on this T32. Of the 52 training grants at the University of Colorado, this is the only one specifically dedicated to aging issues. Because of our success during our last 9 years of funding and our expectations for wider faculty participation, we are now requesting support for 5 pre- and 5 post-doctoral trainees each year. The specific objectives of this training program are to: 1) expand the cohort of faculty mentors interested in aging research;2) recruit and retain outstanding pre- (Ph.D.) and post-doctoral (Ph.D. and M.D.) trainees;3) support their research training through a combination of experiential and didactic instruction;4) insure the highest level of academic success through the conscientious monitoring of a carefully constructed career development plan;5) enhance the mentoring skills of a cadre of "associate mentors" through co-mentoring with a more experienced "primary mentor". These objective will be carried out by offering: 1) up to 2 years of research training support (the second years dependent upon successful progress);2) dual mentoring by outstanding primary and associate mentors;3) a wide variety of relevant classroom experiences on both campuses;4) frequent and careful review of trainee progress/success;5) ongoing appraisal of the program goals, strength and weaknesses;and 6) sound financial and administrative oversight. Our previous success is exemplified by our ability to: 1) fill our positions with outstanding trainees;2) produe academically successful and productive trainees;3) build a pipeline of mentors, and transition trainees to associate mentors and associate mentors to primary mentors;and 4) expand aging-research at both campuses through ongoing collaboration among the participating programs and faculty.

Public Health Relevance

The overall objective of this University of Colorado NRSA is to attract and mentor outstanding pre- (Ph.D.) and postdoctoral (Ph.D. and M.D.) trainees in the Integrative Physiology of Aging. These trainees will be equipped with the skills to become successful, independent academic leaders in the field of aging research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG000279-12
Application #
8459450
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J1))
Program Officer
Eldadah, Basil A
Project Start
2001-05-01
Project End
2017-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
12
Fiscal Year
2013
Total Cost
$482,650
Indirect Cost
$30,910
Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Paxton, Roger J; Feldman-Kothe, Caitlin; Trabert, Megan K et al. (2016) Postural Steadiness and Ankle Force Variability in Peripheral Neuropathy. Motor Control 20:266-84
Pierce, G L; Harris, S A; Seals, D R et al. (2016) Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. J Hum Hypertens 30:513-20
Sharpe, Emily J; St Clair, Joshua R; Proenza, Catherine (2016) Methods for the Isolation, Culture, and Functional Characterization of Sinoatrial Node Myocytes from Adult Mice. J Vis Exp :
Beqollari, Donald; Romberg, Christin F; Dobrowolny, Gabriella et al. (2016) Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis. Skelet Muscle 6:24
Abbate, Lauren M; Perman, Sarah M; Ginde, Adit A et al. (2016) Age Modifies the Association Between Obesity and Mortality in Individuals Hospitalized with Severe Sepsis. J Am Geriatr Soc 64:882-3
Colbert, James F; Traystman, Richard J; Poisson, Sharon N et al. (2016) Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke. J Stroke Cerebrovasc Dis 25:2399-404
Bade, Michael; Struessel, Tamara; Dayton, Michael et al. (2016) Early High-Intensity Versus Low-Intensity Rehabilitation after Total Knee Arthroplasty: A Randomized Controlled Trial. Arthritis Care Res (Hoboken) :
Heveran, Chelsea M; Ortega, Alicia M; Cureton, Andrew et al. (2016) Moderate chronic kidney disease impairs bone quality in C57Bl/6J mice. Bone 86:1-9
Judd, Dana L; Winters, Joshua D; Stevens-Lapsley, Jennifer E et al. (2016) Effects of neuromuscular reeducation on hip mechanics and functional performance in patients after total hip arthroplasty: A case series. Clin Biomech (Bristol, Avon) 32:49-55
Su, Zhen; Hu, Li; Cheng, Jinzhong et al. (2016) Acupuncture plus low-frequency electrical stimulation (Acu-LFES) attenuates denervation-induced muscle atrophy. J Appl Physiol (1985) 120:426-36

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