The proposed program represents a 5-year continuation of an institutional training grant in the biology of aging, which was encompasses diverse investigators from 7 academic departments at UT Health Science Center San Antonio (UTHSCSA). We request funds to support 10 predoctoral and 6 postdoctoral trainees. The impending avalanche of elderly in the US combined with major recent advances in understanding fundamental mechanisms of aging has created a substantial demand for researchers trained to investigate means of delaying and relieving the ailments of an aging population. UTHSCSA is a premier research institution in the biology of aging, with the largest faculty in the country whose research is devoted primarily to the basic biology of aging. The primary goal of the proposed Training Program is to intellectually prepare both graduate students and postdoctoral fellows for careers as leaders in basic biological research in aging. The Training Program involves 26 faculty members (16 men, 10 women) and takes advantage of the synergies created by intensely collaborative personnel, the unique resources available from our Nathan Shock Center of Excellence in the Biology of Aging and the institutional commitment to, and expanding resources of, the Barshop Institute itself. Trainees will be chosen competitively based on academic excellence, their interest in aging research, and motivation for careers in research. The main activity of each trainee is the development of their faculty- supervised research project, which because of the extensive collaboration among our faculty tends to result surprisingly often in co-mentorships. Trainees have thrived with dual mentorships to the point that we have now institutionalized it as an obligatory feature of our training program Another key component is to require broad knowledge in the biology of aging acquired in our biology of aging course such that trainees'can place their research in an appropriate scientific context. In addition to this formal didactic training, we require trainees to attend the weekly Aging Research Journal Club and present at, as well as attend, our weekly Barshop Institute seminar series and annual trainee retreat. Training in grant writing skills resulting in an F- seris grant proposal for individual NRSAs are accomplished by all trainees within the first 18 months of entering our training program.
The tsunami of aging baby-boomers that is about to wash over our healthcare system makes it imperative that we find ways to improve and preserve human health. Basic aging researchers are making many strides towards this goal. Training additional researchers in this field is both scientifically and medically critical.
|Clark, Nathaniel E; Katolik, Adam; Roberts, Kenneth M et al. (2016) Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1. Proc Natl Acad Sci U S A 113:14727-14732|
|Mahoney, Rebekah Elizabeth; Azpurua, Jorge; Eaton, Benjamin A (2016) Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery. Elife 5:|
|Panchal, Shweta; Chitrakar, Reejana; Thompson, Blaine K et al. (2016) Regulation of Stomatal Defense by Air Relative Humidity. Plant Physiol 172:2021-2032|
|Rodriguez, Karl A; Valentine, Joseph M; Kramer, David A et al. (2016) Determinants of rodent longevity in the chaperone-protein degradation network. Cell Stress Chaperones 21:453-66|
|Hambright, W S; Deng, Jie; Tiedje, James M et al. (2016) Shewanella baltica Ecotypes Have Wide Transcriptional Variation under the Same Growth Conditions. mSphere 1:|
|Mishur, Robert J; Khan, Maruf; MunkÃ¡csy, Erin et al. (2016) Mitochondrial metabolites extend lifespan. Aging Cell 15:336-48|
|Triplett, Judy C; Swomley, Aaron M; Cai, Jian et al. (2016) Quantitative phosphoproteomic analyses of the inferior parietal lobule from three different pathological stages of Alzheimer's disease. J Alzheimers Dis 49:45-62|
|Mishra, Anuja; Qiu, Zhifang; Farnsworth, Steven L et al. (2016) Induced Pluripotent Stem Cells from Nonhuman Primates. Methods Mol Biol 1357:183-93|
|Lopez-Cruzan, M; Sharma, R; Tiwari, M et al. (2016) Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment. Cell Death Discov 2:|
|Salmon, Adam B; Lerner, Chad; Ikeno, Yuji et al. (2015) Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I. Am J Physiol Endocrinol Metab 308:E545-53|
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