This application seeks renewal of our T32 training program in "Translational Research in Aging" at the Beth Israel Deaconess Medical Center (BIDMC), a major teaching hospital of Harvard Medical School (HMS). The program will be directed by Dr. Lewis Lipsitz, MD, a well-established clinical investigator and Chief of the BIDMC Gerontology Division, and co-directed by Dr. Konstantin Khrapko, a successful basic scientist and leader in mitochondrial aging.
The specific aims of our program are: 1) To provide a 2-year mentored training program in basic or clinical aging research for six highly qualified, racially and ethnically diverse, postdoctoral trainees each year, and provide them with the skills they need to conduct translational research in aging;2) To provide an 8-12 week short-term research experience and didactic program for six racially and ethnically diverse pre-doctoral PhD candidates each year that will increase the likelihood that they pursue a future academic career in the field of aging;and 3)To promote the translation of basic research findings into interventions that improve the quality of life and well-being of elderly people, by bringing well-established scientists and trainees together across a broad range of basic and clinical research in aging. Over the current funding period we have filled all slots and trained 15 postdoctoral and 27 predoctoral trainees, 4 (27%) and 12 (43%) of whom, respectively, were from ethnic or racial minority backgrounds. Among our 9 postdoctoral graduates, 4 (44%) currently hold full-time junior faculty positions at Boston University, Harvard, and Brown;two are continuing their postdoctoral training as research fellows at BIDMC;one is a clinical psychologist, and 2 have continued their research in industry. One minority trainee has become PI of a NARSAD Young Investigator Award and a NIA-funded R01 diversity supplement. The other minority trainee has obtained a diversity supplement to an R01 held by his mentor, Dr. Khrapko. The proposed post-doctoral program includes mentored research experiences, seminars, coursework, shared laboratory experiences, intensive instruction in responsible scientific conduct, cultural awareness training, a formal evaluation process, and substantive exposure to a multidisciplinary faculty in the field of aging. The training program will continue to facilitate the development of predoctoral students and postdoctoral fellows into independent scientists interested in testing hypotheses concerning aging processes and in deriving and applying interventions to prevent or ameliorate age-associated disease and functional decline.

Public Health Relevance

This training program addresses the critical need for new investigators in the field of aging who can help solve the numerous health-related problems that will soon confront our rapidly aging population. The program will prepare a new cadre of academic leaders in geriatric medicine and aging research, who will be equipped with the necessary skills to understand the aging process, study why it often leads to disease, and determine how to prevent the onset of disease and disability in older adults.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Beth Israel Deaconess Medical Center
United States
Zip Code
Purkayastha, Sushmita; Fadar, Otite; Mehregan, Aujan et al. (2014) Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab 34:228-34
Kim, B M; You, M-H; Chen, C-H et al. (2014) Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function. Cell Death Dis 5:e1237
Fajardo, Roberto J; Karim, Lamya; Calley, Virginia I et al. (2014) A review of rodent models of type 2 diabetic skeletal fragility. J Bone Miner Res 29:1025-40
Mangano, Kelsey M; Sahni, Shivani; Kerstetter, Jane E (2014) Dietary protein is beneficial to bone health under conditions of adequate calcium intake: an update on clinical research. Curr Opin Clin Nutr Metab Care 17:69-74
Vasunilashorn, Sarinnapha; Cohen, Alan A (2014) Stress responsive biochemical anabolic/catabolic ratio and telomere length in older adults. Biodemography Soc Biol 60:174-84
Winslow, Ashley R; Moussaud, Simon; Zhu, Liya et al. (2014) Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain 137:1958-70
Manor, Brad; Lough, Matt; Gagnon, Margaret M et al. (2014) Functional benefits of tai chi training in senior housing facilities. J Am Geriatr Soc 62:1484-9
Anderson, Dennis E; Madigan, Michael L (2014) Healthy older adults have insufficient hip range of motion and plantar flexor strength to walk like healthy young adults. J Biomech 47:1104-9
Sahni, Shivani; Mangano, Kelsey M; Tucker, Katherine L et al. (2014) Protective association of milk intake on the risk of hip fracture: results from the Framingham Original Cohort. J Bone Miner Res 29:1756-62
Gross, Alden L; Brandt, Jason; Bandeen-Roche, Karen et al. (2014) Do older adults use the method of loci? Results from the ACTIVE study. Exp Aging Res 40:140-63

Showing the most recent 10 out of 74 publications