This is the first competitive renewal application for the University of California (UCSF) multidisciplinary post- doctoral training program in Behavioral Neurology and neurodegenerative disease, directed by Bruce Miller, M.D. The goal of the program is to train future leaders in Behavioral Neurology research. The program is currently in its fourth year of funding. It has attracted a diverse and highly accomplished group of applicants and funded the training of seven neurologists, who came from prestigious Neurology residencies. Four of the fellows have completed our program and have moved into stable academic positions where they pursue excellence in research, education and clinical care, while three others are continuing their training. The proposed grant would provide continued support for two-year fellowships that will combine a diverse set of clinical experiences with didactics. First year clinical experience will include time in the Behavioral Neurology clinic, the Alzheimer's Disease Research Center, the program project grant for assessment of FTD and related disorders, the UCSF clinical trials program for degenerative dementias, and the rapidly progressive dementia program. Didactics will be provided through new courses designed specifically for this program by our faculty. The lectures tackle key topics relevant to Behavioral Neurology and neurodegenerative disease, including clinical presentation, basic biology, neuroimaging, data management and analysis, study design, and brain-behavior influences upon ethical behavior. These courses will be made available via the Internet as a formal curriculum for use by other training programs. During the second year, fellows will shift focus towards basic research, working with a specific research mentor, and spend less time with clinical duties. The list of available mentors includes accomplished researchers working in a variety of disciplines related to dementia, including cognitive and behavioral assessment, neuroimaging, and epidemiology and bench research. The program will support three new fellows per year for fellowships that will be open to neurologists, psychiatrists, geriatricians or neuropsychologists.

Public Health Relevance

The rapid pace of dementia research suggests that there will be an increasing need for dementia researchers in the future. These investigators will need to be adept at early and accurate diagnosis, familiar with the design and logistics of clinical studies, and comfortable dealing with ethical issues. The proposed program will incorporate all these elements into the training of future dementia researchers.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Institutional National Research Service Award (T32)
Project #
5T32AG023481-09
Application #
8463436
Study Section
Special Emphasis Panel (ZAG1-ZIJ-3 (J3))
Program Officer
Silverberg, Nina B
Project Start
2005-05-01
Project End
2015-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
9
Fiscal Year
2013
Total Cost
$136,599
Indirect Cost
$14,051
Name
University of California San Francisco
Department
Neurology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Pressman, Peter S; Miller, Bruce L (2014) Diagnosis and management of behavioral variant frontotemporal dementia. Biol Psychiatry 75:574-81
Perry, David C; Sturm, Virginia E; Seeley, William W et al. (2014) Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia. Brain 137:1621-6
You, S Christine; Geschwind, Michael D; Sha, Sharon J et al. (2014) Executive functions in premanifest Huntington's disease. Mov Disord 29:405-9
Chao, Steven Z; Rosen, Howard J; Azor, Virgina et al. (2013) Frontotemporal dementia in eight Chinese individuals. Neurocase 19:76-84
Perry, David C; Lehmann, Manja; Yokoyama, Jennifer S et al. (2013) Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol 70:774-8
Miller, Zachary A; Mandelli, Maria Luisa; Rankin, Katherine P et al. (2013) Handedness and language learning disability differentially distribute in progressive aphasia variants. Brain 136:3461-73
Chao, Steven Z; Lai, Ngan B; Tse, Marian M et al. (2011) Recruitment of Chinese American elders into dementia research: the UCSF ADRC experience. Gerontologist 51 Suppl 1:S125-33
Perry, David C; Geschwind, Michael D (2011) Thorough work-up and new diagnostic criteria needed for CJD. Nat Rev Neurol 7:479-80
Rankin, Katherine P; Mayo, Mary Catherine; Seeley, William W et al. (2011) Behavioral variant frontotemporal dementia with corticobasal degeneration pathology: phenotypic comparison to bvFTD with Pick's disease. J Mol Neurosci 45:594-608
Lee, Suzee E; Rabinovici, Gil D; Mayo, Mary Catherine et al. (2011) Clinicopathological correlations in corticobasal degeneration. Ann Neurol 70:327-40

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