The Integrative Immunology Training Program (IITP) at the University of Texas Southwestern Medical Center (UT Southwestern) will provide comprehensive training to pre-doctoral students, medical scientist trainees, and post-doctoral fellows, preparing them for careers in immunology-related research fields. The goal of our 35 year old training program is to train top-quality scientists to investigate and resolve significant immune-related problems. Our advanced immunology training will provide trainees with the essential skills necessary to respond to global health issues such as emerging infectious diseases, an aging population suffering the ills of autoimmune diseases, and health care crises involving metabolic disorders (diabetes), cardiovascular diseases, and cancer, which are dramatically affected by the immune response. The training will include cutting edge research, intellectually challenging didactic immunology courses, works-in-progress seminars, a research proposal writing class, multiple lecture series, and journal clubs. We have an excellent program- specific plan to recruit and retain a geographically broad range of pre- and post- doctoral applicants as well as underrepresented minority trainees. Included in our training program is course work on the responsible conduct of research, ethics classes, statistics workshops, and enhanced scientific/research dialog. In addition, we provide our trainees with exposure to clinical settings using case presentations with attending physicians at nationally ranked Medical Centers. The UT Southwestern Immunology/Infectious Diseases Graduate Program is ranked 9th in the nation, and our current training mechanisms will enable us to continue as a leader in training highly qualified individuals. UT Southwestern Medical Center is committed to this training mechanism, supporting the administrative personnel and core facilities on campus that are necessary to achieve our goals.

Public Health Relevance

This T32 renewal application provides a comprehensive description of the recruitment, training and retention program for immunology trainees engaged in cutting edge immunology research. A very strong research component, in conjunction with challenging courses, excellent lecture series, and a unique training environment with innovative approaches and evaluation strategies distinguishes it from other training programs. Our goals are to train top-quality scientists capable of conducting independent immunology research and to promote the development of essential intellectual, technical, and communication skills that are needed for success in the academic and/or industrial arenas of today and tomorrow.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Allergy & Clinical Immunology-1 (AITC)
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Prograis, Lawrence J
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University of Texas Sw Medical Center Dallas
Schools of Medicine
United States
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Chen, Ding; Ireland, Sara J; Remington, Gina et al. (2016) CD40-Mediated NF-κB Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J Immunol 197:4257-4265
Estrada, Leonardo D; Ağaç, Didem; Farrar, J David (2016) Sympathetic neural signaling via the β2-adrenergic receptor suppresses T-cell receptor-mediated human and mouse CD8(+) T-cell effector function. Eur J Immunol 46:1948-58
Pendse, Mihir; Hooper, Lora V (2016) Immunology: Mum's microbes boost baby's immunity. Nature 533:42-3
Starokadomskyy, Petro; Gemelli, Terry; Rios, Jonathan J et al. (2016) DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis. Nat Immunol 17:495-504
Nair, Vidhya R; Franco, Luis H; Zacharia, Vineetha M et al. (2016) Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection. Cell Rep 16:1253-8
Scharn, Caitlyn R; Collins, Angela C; Nair, Vidhya R et al. (2016) Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection. J Immunol 196:4641-9
Orme, Jacob J; Du, Yong; Vanarsa, Kamala et al. (2016) Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE. Clin Immunol 169:58-68
Sun, Jing; Li, Ning; Oh, Kyu-Seon et al. (2016) Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use. Sci Signal 9:ra3
Pokatayev, Vladislav; Hasin, Naushaba; Chon, Hyongi et al. (2016) RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. J Exp Med 213:329-36
Case, Allison; Desmond, Angela; Lopes, Daniel et al. (2016) The Immunogenicity of Peptoid-Protein Conjugates. J Vaccines Vaccin 7:

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